職稱：副教授、碩士生導(dǎo)師

學(xué)歷：博士研究生

電話：14759759282

電子郵件：juanyang@fzu.edu.cn

研究方向：蛋白質(zhì)化學(xué) 結(jié)構(gòu)生物學(xué)

教育工作經(jīng)歷：

2019.06—至今     beat365在線體育官網(wǎng)，beat365在線體育官網(wǎng)   副教授

2015.05—2019.05  beat365在線體育官網(wǎng)，beat365在線體育官網(wǎng)   講師

2011.09—2015.04  廈門大學(xué)，化學(xué)生物學(xué)專業(yè)理學(xué)   博士

2011.04—2011.09  中國科學(xué)院上海藥物研究所交流學(xué)習(xí)

2008.09—2011.03  華東理工大學(xué)，制藥工程與技術(shù)專業(yè)工學(xué)  碩士

2004.09—2008.07  鄭州大學(xué)，制藥工程專業(yè)工學(xué)      學(xué)士

教學(xué)簡介：

講授本科生課程：《基因工程》、《結(jié)構(gòu)生物學(xué)》和《常用生物工程軟件應(yīng)用》

承擔(dān)本科生實驗課程：《免疫組化實驗》

科研簡介：

主要從事疾病相關(guān)的蛋白質(zhì)靶點與藥物之間相互作用的構(gòu)效關(guān)系及藥物調(diào)控機(jī)制的研究，將結(jié)構(gòu)生物學(xué)、分子生物學(xué)、細(xì)胞生物學(xué)與生物化學(xué)等研究手段相結(jié)合，從藥物與靶標(biāo)的構(gòu)效關(guān)系、藥物作用的生理和病理機(jī)制以及藥物調(diào)控的分子機(jī)理等方面開展研究，為新藥的研發(fā)提供結(jié)構(gòu)基礎(chǔ)和理論指導(dǎo)。目前已在Molecular Microbiology，Org.Lett.，Synthesis，J.Med.Chem.，Nat. Prod. Bioprospect，Protein expression and purification，Acta Biochim Biophys Sin等國際學(xué)術(shù)期刊上發(fā)表SCI論文多篇，并獲得國內(nèi)發(fā)明專利兩項。

科研項目：

1. 國家自然科學(xué)基金（青年基金），人源程序性死亡受體PD-1與其配體PD-L2負(fù)性調(diào)控免疫應(yīng)答的結(jié)構(gòu)基礎(chǔ)研究，項目編號31700656，項目起止時間2018.01—2020.12，主持；

2. 福建省自然科學(xué)基金（青年基金），人程序性死亡配體PD-1與其配體PD-L2調(diào)節(jié)免疫應(yīng)答的結(jié)構(gòu)基礎(chǔ)和功能研究，項目編號2017J05050，項目起止時間 2017.04-2020.04，主持；

3. beat365在線體育官網(wǎng)校人才項目，人源B7家族PD-1-PD-L2通路調(diào)節(jié)免疫應(yīng)答的結(jié)構(gòu)基礎(chǔ)，項目起止時間2015.5—2017.5，主持。

代表性論文：（*為通訊作者）

1. Juanjuan Yang, Jing Hong, Ling Luo, Ke Liu, Chun Meng, Zhi-liang Ji, Donghai Lin*. Biophysical characterization and ligand-binding properties of the elongation factor Tu from Mycobacterium tuberculosis. Acta Biochim Biophys Sin, 2019, 51(2):139-149.

2. Yunbao Zhi, Yazhuang Dai, Juanjuan Yang, Shuhua Tan, Donghai Lin, Kejiang Lin*. Lead compounds and key residues of ribosomal protein S1 in drug-resistant Mycobacterium tuberculosis.Bioorganic Chemistry, 2019, 82: 58-67.

3. Yang Yang, Zhen Liu, Xiaoqin He, Juanjuan Yang, Jing Wu, Hailong Yang, Min Li, Qian Qian, Ren Lai*, Wei Xu* and Lin Wei*. A small mycobacteriophage-derived peptide and its improved isomer restrict mycobacterial infection via dual mycobactericidal-immunoregulatory activities. Journal of Biological Chemistry, 2019, 294(19): 7615-7631.

4. Taotao Chen, Zheng Chen, Huimin Wang, Xiaodong Chen, Juanjuan Yang, Aidong Han, Dong-Hai Lin, Jing Hong*. Underlying action mechanism of a novel antioxidant peptide derived from Allium tuberosum Rottler protein hydrolysates and its protective e?ects on hydrogen peroxide induced cell injury. Journal of Functional Foods, 2018, 40: 606-613.

5. Juanjuan Yang, Yindi Liu, Shuli Xu, Haiying Lin, Chun Meng, Donghai Lin*. Expression, puri?cation and characterization of the full-length SmpB protein from Mycobacterium tuberculosis. Protein expression and purification, 2018, 151: 9-17.

6. Juanjuan Yang, Lei Hu, Tiantian Cai, Qiuluan Chen, Qian Ma, Jie Yang, Chun Meng, Jing Hong*. Purification and identification of two novel antioxidant peptides from perilla (Perilla Frutescens L. Britton) seed protein hydrolysates. PLoS One, 2018, 13(7): 1-15.  

7. Lixian Mu, Lei Zhou, Juanjuan Yang, Li Zhuang, Jing Tang, Tong Liu, Jing Wu, Hailong Yang*. The first identified cathelicidin from tree frogs possesses anti?inflammatory and partial LPS neutralization activities. Amino Acids, 2017, 49: 1571-1585.

8. Juanjuan Yang, Yindi Liu, Zhao Liu, Chun Meng, Donghai Lin*. Backbone and side-chain resonance assignments for the tmRNA binding protein, SmpB, from Mycobacterium tuberculosis. Biomolecular NMR Assignments, 2017, 11(2): 175-179.

9. Juanjuan Yang, Yindi Liu, Jing Bi, Qixu Cai, Xinli Liao, Wenqian Li, Chenyun Guo, Qian Zhang, Tianwei Lin, Yufen Zhao, Honghai Wang, Jun Liu*, Xuelian Zhang*, Donghai Lin*. Structural basis for targeting the ribosomal protein S1 of Mycobacterium tuberculosis by pyrazinamide. Molecular Microbiology, 2015, 95(5), 791-803. 

10. Lin Wei, Chunjing Huang, Hailong Yang, Min Li, Juanjuan Yang, Xue Qiao, Lixian Mu, Fei Xiong, Jing Wu*, Wei Xu*. A potent anti-inflammatory peptide from the salivary glands of horsefly. Parasit Vectors, 2015, 8: 556-556.

11. Lin Wei§, Juanjuan Yang^§, Xiaoqin He, Guoxiang Mo, Jing Hong, Xiuwen Yan*, Donghai Lin*, Ren Lai*. Structure and Function of a Potent Lipopolysaccharide-Binding Antimicrobial and Anti-inflammatory Peptide. J. Med.Chem. 2013, 56: 3546-3556(§, co-first author).

12.  Li Dong^§, JuanJuan Yang^§, Ying Wang, Huan Liu, LiXian Mu, Donghai Lin*, Ren Lai*. Structure-function  relationship  of  antimicrobial  peptide cathelicidin Pc-CATH1. Nat. Prod. Bioprospect., 2012, 2: 81–86 (§, co-first author).

13. Juanjuan Yang, Huicai Huang,  Zhichao Jin, Wenbin Wu, Jinxing Ye*. Diastereoselective Synthesis of Bicyclo[2.2.2]octan-2-one Derivatives through an Unexpected Organocatalytic Tandem Michael–Michael Reaction. Synthesis, 2011, 12: 1984-1987. 

14. Wenjun Li, Wenbin Wu, Juanjuan Yang, Xinmiao Liang, Jinxing Ye. As*, Asymmetric Direct Michael Addition of Acetophenone to α, β-Unsaturated Aldehyde. Synthesis, 2011, 7:1085-1091.

15. Juanjuan Yang, Wenjun Li, Zhichao Jin, Xinmiao Liang, Jinxing Ye*. Enantioselective  Michael  Reaction  of α-Alkyl-β-keto Esters and Enones under Multifunctional Catalysis. Org. Lett., 2010, 12: 5218-5221.

16. Chunlin Wu, Wenjun Li, Juanjuan Yang, Xinmiao Liang*, Jinxing Ye*. Asymmetric organocatalytic Michael addition of anthrone to enone, Org. Biomol. Chem., 2010, 8: 3244-3250.

專利申請：

1. 一種人源程序性死亡受體hPD-1單克隆抗體：楊娟娟，孟春，呂唯，劉照，吳茂，授權(quán)專利號 ZL 201611197005.3。

2. 一種人源程序性死亡因子配體hPD-L2單克隆抗體：楊娟娟，孟春，劉照，羅嶺，夏菁潞，徐淑麗授權(quán)專利號：2017102780143。

獲獎情況

1. 2018.11 beat365在線體育官網(wǎng)beat365在線體育官網(wǎng) 青年教師“最佳一節(jié)課”教學(xué)競賽三等獎

2. 2017.11 指導(dǎo)全國大學(xué)生生命科學(xué)競賽 獲得三等獎

3. 2017.06 beat365在線體育官網(wǎng)優(yōu)秀本科畢業(yè)論文指導(dǎo)老師