職稱：教授,博士生導師

學歷：博士研究生

電話：

電子郵件：xiuyunye@fzu.edu.cn

研究方向：蛋白質與酶工程、微生物資源的開發與利用、酶制劑及其它生物活性物質的分子生物學和基因工程改良、食品生物技術；

教育工作經歷：

1979.09-1983.07 beat365在線體育官網化學化工系；大學本科

1983.07-1986.05 福建省南靖合成氨廠；助理工程師

1986.05-1989.10 福建省化工設計院；助理工程師

1989.10-1992.03 日本國廣島大學應用生物學系；碩士研究生

1992.03-1995.03 日本國廣島大學應用生物學系；博士研究生

1995.03-1996.04 日本國農林水產省食品綜合研究所；博士后

1996.04-1997.09 加拿大農業部列橋研究中心；博士后

1997.09-2002.05 香港中文大學醫學院生物化學系；博士后、研究員.

2002.05-至今 beat365在線體育官網beat365在線體育官網；特聘教授，教授

教學簡介：

承擔的《蛋白質化學》課程被評為福建省精品課程，獲福建省教學成果二等獎4項。

科研簡介：

長期從事基因工程在酶制劑工業中的應用研究與開發，在酶制劑及其它生物活性物質的分子生物學和基因工程改良、高效表達等方面積累了豐富的經驗，并取得了豐碩的科研成果。對不同環境微生物的認識與利用，建立了產酶微生物資源庫和微生物酶基因資源庫；開發不同環境來源酶等新產物，重點開展酶制劑在海洋生物資源、寡糖生產、食品、生物醫藥開發中的應用，探討生物催化的應用途徑。

主持了國家海洋局海洋公益性行業科研專項、863子課題、國家自然科學基金、福建省發改委產業技術開發專項、福建省經貿委企業技術創新專項等10多項國家及省部級重大科研項目的研究工作。研究成果獲得了國家技術發明獎二等獎，國家科技進步二等獎，中國輕工業聯合會科學技術發明獎一等獎，省科技進步二、三等獎，省專利三等獎等多項獎勵；授權國家發明專利18項，國際發明專利2項；在國際性影響因子較高的專業學術刊物上先后發表了學術論文100多篇，其中被SCI收錄的論文達80多篇；參與出版專著2部，教材2部。

社會兼職：

1、 酶高效表達國家工程實驗室主任；

2、 福建省海洋酶工程重點實驗室主任；

3、 福建省食品生物技術開發基地主任；

4、 農工黨福建省省委常委，農工黨beat365在線體育官網主委；

5、 福建省食品科學技術學會副理事長，福建省食品安全專家，福建省保健食品安全專家；

科研項目：

1、國家海洋局“海洋酶工程創新服務平臺”（2017-2020）

2、國家海洋局海洋公益性行業科研專項“幾種海洋生物酶及系列功能產品研發與應用示范”（2013-2016）；

3、國家科技部863子課題“新型糖酶創制與創新應用關鍵技術研究”（2013-2017）；

4、福建省海洋高新產業發展專項“海洋生物酶研發及產業化平臺建設”（2013-2016）；

5、福建省經貿委“功能食品研究與開發共享平臺的建設”（2012-2014）；

6、福建省經貿委“食品微生物菌種資源共享平臺的建設”（2010-2012）；

7、 福建省經貿委“食品酶工程應用技術服務平臺建設”（2009-2011）；

8、福建省發改委產業技術開發專項“轉基因鹿茸促成骨細胞生長因子的高效表達及工業化生產技術”（2009-2011）；

9、國家自然科學基金項目“鹿茸促成骨細胞生長協同作用組分的分離鑒定及其分子作用機理研究”（2007-2009）.

代表性論文：

1.Xu X.Q., Su B.M., Xie J.S., Li R.K., Yang J., Lin J.and Ye X.Y. (2018). Preparation of bioactive neoagaroligosaccharides through hydrolysis of Gracilaria lemaneiformis agar: A comparative study. Food Chemistry,

2. Wang G., Wu J., Yan R., Lin J.andYe X.Y. (2017).A Novel Multi-domain High Molecular, Salt-Stable Alkaline Xylanase from Alkalibacterium sp. SL3. Front Microbiol 7: 2120.

3. Yang, J., Lin, Y., Yang, X., Ng, T. B., Ye, X.Y.and Lin, J (2017). Degradation of tetracycline by immobilized laccase and the proposed transformation pathway. Journal of Hazardous Materials, 322, 525-531.

4. Wang G., Wang Q., Lin X., Ng T.B., Yan R., Lin J.andYe X.Y.(2016). A novel cold-adapted and highly salt-tolerant esterase from Alkalibacterium sp. SL3 from the sediment of a soda lake. Sci Rep 6: 19494.

5. Yang J., Xu, X., Yang, X., Ye, X.Y and Lin, J (2016). Cross-linked enzyme aggregates of Cerrena laccase: preparation, enhanced NaCl tolerance and decolorization of Remazol Brilliant Blue Reactive. Journal of the Taiwan Institute of Chemical Engineers, 65, 1-7.

6. Yang J., Yang X., Ye X.Y. and Lin, J. (2016). Optimal parameters for laccase-mediated destaining of Coomassie Brilliant Blue R-250-stained polyacrylamide gels. Data in Brief, 7, 1-7.

7. Yang, J., Yang, X., Ye, X.Y. and Lin, J. (2016). Destaining of Coomassie Brilliant Blue R-250-stained polyacrylamide gels with fungal laccase. Analytical Biochemistry, 493, 27-29.

8. Yang, J., Wang, G., Ng, T. B., Lin, J., and Ye, X.Y. (2016). Laccase production and differential transcription of laccase genes in Cerrena sp. in response to metal ions, aromatic compounds, and nutrients. Frontiers in Microbiology, 6, 1558.

9. Ng T.B., Cheung R.C., Wong J.H., Chan Y.S., Dan X., Pan W., Wang H., Guan S, Chan K, Ye X.Y., Liu F, Xia L, Chan WY (2016). Fungal proteinaceous compounds with multiple biological activities, Appl Microbiol Biotechnol., 100(15):6601-17.

10. Yang J., Xu, X., Ng, T. B., Lin, J., and Ye, X.Y.(2016). Laccase gene family in Cerrena sp. HYB07: sequences, heterologous expression and transcriptional analysis. Molecules, 21, 1017.

11. Li R.K., Chen P., Ng T.B., Yang J., Lin J., Yan F., and Ye X.Y.(2015). Highly efficient expression and characterization of a β-mannanase from Bacillus subtilis in Pichia pastoris.Biotechnol Appl Biochem. 62(1):64-70

12. Wang G., Wu J., Lin J., Ye X.Y. and Yao B. (2016). The disruption of two salt bridges of the cold-active xylanase XynGR40 results in an increase in activity, but a decrease in thermostability. Biochem Biophys Res Commun 481: 139-145.

13. Yang, J., Yang, X., Lin, Y., Ng, T. B., Lin, J. and Ye, X.Y. (2015) Laccase-catalyzed decolorization of malachite green: Performance optimization and degradation mechanism. PLoS ONE, 10, e0127714

14. Huang X., Lin J., Ye X.Y.and Wang G. (2015). Molecular Characterization of a Thermophilic and Salt- and Alkaline-Tolerant Xylanase from Planococcus sp. SL4, a Strain Isolated from the Sediment of a Soda Lake. J Microbiol Biotechnol 25: 662-671.

15. Yang, J., Lin, Q., Lin, J., and Ye, X.Y. (2016). Selection and validation of reference genes for quantitative real-time polymerase chain reaction studies in Cerrena unicolor (higher basidiomyetes). International Journal of Medicinal Mushrooms, 18, 165-175.

16 Yang, J., Ng, T. B., Lin, J. and Ye, X.Y. (2015).A novel laccase from basidiomycete Cerrena sp.: Cloning, heterologous expression, and characterization. International Journal of Biological Macromolecules, 77, 344-349.

17. Yang, J., Lin, Q., Ng, T. B., Ye, X.Y. and Lin, J (2014).Purification and characterization of a novel laccase from Cerrena sp. HYB07 with dye decolorizing ability. PLoS ONE, 9, e110834.

18. Wang G., Huang X., Ng T.B., Lin J.andYe X.Y.(2014).High phylogenetic diversity of glycosyl hydrolase family 10 and 11 xylanases in the sediment of Lake Dabusu in China.PLoS One 9: e112798.

19. Li R.K., Fu C.L., Chen P., Ng T.B. and Ye X.Y. (2013). High-level expression of a sika deer (Cervus nippon) Cu/Zn superoxide dismutase in Pichia pastoris and its characterization. Environ Toxicol Pharmacol. 35(2):185-92.

20. Wang S.Y., Ye X.Y. and Rao P.F. (2012). Isolation of a novel leguminous lysozyme and study on the antifungal activity.Food research international, 47(2):341-347

21. Wang S.Y., Shao B., Liu S.T., Ye X.Y. and Rao P.F. (2012). Purification and characterization of Cu, Zn-superoxide dismutase from black soybean.Food research international, 47(2):374-379

22. Wang S.Y., Ye X.Y., Chen J. and Rao P.F. (2012). A novel chitinase isolated from Vicia faba and its antifungal activity. Food research international, 45(1):116-122

23.Ng T.B., Wong J.H, Fang EF, Chan YS, Pan W, Ye X.Y., Sze SC, Zhang KY, Liu F, Wang HX (2011) Glyceollin, a soybean phytoalexin with medicinal properties. Appl Microbiol Biotechnol.90(1):59-68.

24. Shaoyun Wang S. Y,. Biao Shao B., Liu S T., Ye X.Y., Pingfan Rao (2011) Purification and characterization of Cu, Zn-superoxide dismutase from black soybean.Food Research International.

25. Ng T. B.，Jack Ho Wong，Evandro Fei Fang，Yau Sang Chan，Wenliang Pan，Xiu Yun Ye，Stephen Cho Wing Sze，Kalin Yanbo Zhang，Fang Liu，He Xiang Wang.Glyceollin, a soybean phytoalexin with medicinal properties. Applied Microbiology and Biotechnology. 2011.Apr;90(1):59-68. Epub 2011 Feb 20

26. Jack H. Wong，T. B. Ng，Randy C. F. Cheung，X. J. Ye，H. X. Wang，S. K. Lam，P. Lin，Y. S. Chan，Evandro F. Fang，Patrick H. K. Ngai，L. X. Xia，X. Y. Ye，Y. Jiang，F. Liu.2010. Proteins with antifungal properties and other medicinal applications from plants and mushrooms. Appl Microbiol Biotechnol. Jul;87(4):1221-35

27. Shaoyun Wang¹, Pingfan Rao¹ and Xiuyun Ye¹ .Isolation and biochemical characterization of a novel leguminous defense peptide with antifungal and antiproliferative potency.Appl Microbiol Biotechnol. 2009 Feb;82(1):79-86.

28. Shaoyun Wang¹, Pingfan Rao¹ and Xiuyun Ye¹ .Isolation and biochemical characterization of a novel leguminous defense peptide with antifungal and antiproliferative potency.Appl Microbiol Biotechnol. 2009 Feb;82(1):79-86.

29. Wang S, Shao B, Rao P, Lee Y, Ye X.Y. Hypotin, a novel antipathogenic and antiproliferative protein from peanuts with a sequence similar to those of chitinase precursors.  J Agric Food Chem. 2007 Nov 28;55(24):9792-9. Epub 2007 Nov 3.

PMID: 17979231 [PubMed - indexed for MEDLINE]

30. Lin P, Xia L, Wong JH, Ng TB, Ye X.Y, Wang S, Shi X. Lipid transfer proteins from Brassica campestris and mung bean surpass mung bean chitinase in exploitability. J Pept Sci. 2007 Oct;13(10):642-8.

31.Wang S, Lin J, Ye M, Ng TB, Rao P, Ye XY. Isolation and characterization of a novel mung bean protease inhibitor with antipathogenic and anti-proliferative activities.Peptides. 2006 ec;27(12):3129-36.

32. Wang SY，Xu Z B，Ye XY, Rao P F. 2005. Purification and characterization of a malate dehydrogenase from Phaseolus mungo. Journal of food biochemistry, 29(2): 117-131.

33. Lin DY, Huang XN, Ke LJ, Chen XC, Ye XY, Huo YS, Rao PF, 2005. Purification and characterization of the proliferation of rat osteoblast-like cells UMR-106 from pilose antler. Zhongguo Zhong Yao Za Zhi. Jun;30(11):851-5

34. Wang SY, Wu J, Rao PF, Ng TB, Ye XY. 2005. A chitinase with antifungal activity from the mung bean.Protein Expr. Purif. Apr;40(2):230-6.

35. Wang SY, Ng TB, Chen T. Lin D, Wu J. Rao PF, Ye XY. 2005. First report of a novel plant lysozyme with both antifungal and antibacterial activities. Biochem. Biophys. Res. Commun. Feb 18;327(3):820-7.

36. Wang SY, Zhou KJ, Ye XY, Xu ZB, Wu JH, Rao PF. 2004. Crystallization and preliminary X-ray crystallographic analysis of a non-specific lipid-transfer protein with antipathogenic activity from Phaseolus mungo.Acta Crystallogr D Biol Crystallogr. Dec;60(Pt 12 Pt 2):2391-3. Epub 2004 Nov

37. Wang SY, Wu JH, Ng TB, Ye XY and Rao PF. 2004.A non-specific lipid transfer protein with antifungal and antibacterial activities from the mung bean. Peptides. 2004 Aug;25(8):1235-42.

38. Ng TB and Ye X.Y.2004. A polymeric immunoglobulin receptor-like milk protein with inhibitory activity on human immunodeficiency virus type 1 reverse transcriptase. Int J Biochem Cell Biol. 2004 Nov;36(11):2242-9.

39. Ng TB and Ye X.Y.2003. Fabin, a novel calcyon-like and glucanase-like protein with mitogenic, antifungal and translation-inhibitory activities from broad beans. Biol Chem. 2003 May;384(5):811-5.

40. Ye, X. Y. and Ng, T. B.2003.Purification and characterization of a new ribonuclease from fruiting bodies of the oyster mushroom Pleurotus ostreatus. J Pept Sci. 2003 Feb;9(2):120-4.

41. Ye, X. Y. and Ng, T. B.2003.Isolation of vulgin, a new antifungal polypeptide with mitogenic activity from the pinto bean. J Pept Sci. 2003 Feb;9(2):114-9.

42. Ye, X. Y. and Ng, T. B.2003.Isolation of pisumin, a novel antifungal protein from legumes of the sugar snap pea Pisum sativum var macrocarpon. Comp Biochem Physiol C Toxicol Pharmacol. 2003 Feb;134(2):235-40.

43. Ye, X. Y. and Ng, T. B.2002.A new peptidic protease inhibitor from Vicia faba seeds exhibits antifungal, HIV-1 reverse transcriptase inhibiting and mitogenic activities. J Pept Sci. 2002 Dec;8(12):656-62.

44. Ye, X. Y. and Ng, T. B.2002. Isolation of a novel peroxidase from French bean legumes and first demonstration of antifungal activity of a non-milk peroxidase. Life Sci. Aug 23;71(14):1667-1680.

45. Ye, X. Y. and Ng, T. B.2002. A new antifungal peptide from rice beans.J. Pept. Res. Aug;60(2):81-7.

46. Ye, X. Y. and Ng, T. B.2002. A novel peptide with ribonuclease and translation-inhibitory activities from fruiting bodies of the oyster mushroom Pleurotus ostreatus. J. Pept. Sci. Jun;8(6):235-40.

47. Ye, X. Y. and Ng, T. B.2002. Cicerin and arietin, novel chickpea peptides with different antifungal potencies. Peptides. May;23(5):817-22.

48. Ye, X. Y. and Ng, T. B.2002. A novel and potent ribonuclease from fruiting bodies of the mushroom Pleurotus pulmonarius. Biochem. Biophys. Res. Commun. May 3;293(2):857-61.

49. Ye, X. Y. and Ng, T. B.2002. Purification of angularin, a novel antifungal peptide from adzuki beans. J. Pept. Sci. Mar;8(3):101-6.

50. Ye, X. Y. and Ng, T. B.2002. Delandin, a Chitinase-like Protein with Antifungal, HIV-1 Reverse Transcriptase Inhibitory and Mitogenic Activities from the Rice Bean Delandia umbellata. Protein Expr Purif. Apr;24(3):524-9.

51. Ng, T. B., Lam, T. L., Au, T. K., Ye, X. Y. and Wan, C. C. 2002. Inhibitory effects of antifungal proteins on human immunodeficiency virus type 1 reverse transcriptase, protease and integrase. Life Sci.  Jan 11;70(8):927-35.

52. Ye, X. Y. and Ng, T. B.2002. Isolation of a new cyclophilin-like protein from chickpeas with mitogenic, antifungal and anti-HIV-1 reverse transcriptase activities. Life Sci. Jan 25;70(10):1129-38.

53. Ye, X. Y. and Ng, T. B.2002. A new antifungal protein and a chitinase with prominent macrophage-stimulating activity from seeds of Phaseolus vulgaris cv. pinto. Biochem. Biophys. Res. Commun. Jan 18;290(2):813-9.

獲獎情況：

教學：獲福建省教學成果二等獎4項。

科研：獲國家技術發明獎二等獎，國家科技進步二等獎，中國輕工業聯合會科學技術發明獎一等獎，省科技進步二、三等獎，省專利三等獎等多項獎勵。

新世紀百千萬人才工程省級人選。

其他