職稱：副教授

學歷：博士研究生

電子郵件：qushuai@pku.edu.cn

研究方向：基因治療；脂質納米顆粒（LNP）；超聲介導的藥物遞送

研究生招生專業：生物醫學工程（學碩）、生物技術與工程（專碩）

教育工作經歷：

2024.08-至今：beat365在線體育官網，beat365在線體育官網，副教授

2018.09-2024.07：北京大學，生物醫學工程專業，博士研究生

2014.09-2018.07：哈爾濱工業大學，生物工程專業，本科

科研簡介：

專注于開發高效、特異的體內基因遞送策略。通過篩選優化脂質納米粒（LNP）及設計優化mRNA序列，使其能夠聯合超聲靶向微泡空化實現靶向體內特定組織器官乃至特定類群細胞遞送mRNA，同時屏蔽外源mRNA在非超聲輻照部位的表達，實現體內定點的基因表達乃至基因編輯，用于治療動脈粥樣硬化、癌癥等疾病。

其他：光動力療法（PDT）

代表性論文：

[1] Qu, S^#., Liu, R^#., Zhang, N., Xu, Y., Yue, X., & Dai, Z. (2022). Non-viral nucleic acid therapeutics: Revolutionizing the landscape of atherosclerotic treatment. Nano Today, 45, 101514.

[2] Liu, R^#., Qu, S^#., Xu, Y., Jo, H., & Dai, Z. (2022). Spatial control of robust transgene expression in mouse artery endothelium under ultrasound guidance. Signal Transduction and Targeted Therapy, 7(1), 225.

[3] Qu, S., Liu, R., & Dai, Z. (2022). Imaging-guided gene delivery: seeing is delivering. Journal of Bio-X Research, 5(04), 143-144.

[4] Xin, Z., Qu, S., Qu, Y., Xu, Y., Liu, R., Sun, D., & Dai, Z. (2024). Emerging IL-12-based nanomedicine for cancer therapy. Nano Today, 57, 102331.

[5] Liu, R^#., Yang, H^#., Qu, S., Yang, P., Zhi, X., Xu, Y., Dai, Z., Qian, L (2023). Photodynamic eradication of intratumoral microbiota with bacteria-targeted micelles overcomes gemcitabine resistance of pancreatic cancer. Aggregate, 00, e423.

[6] Liu, R., Xu, Y., Qu, S., & Dai, Z. (2023). Major Strategies for Spatial Control of Ultrasound-Driven Gene Expression to Enhance Therapeutic Specificity. Critical Reviews? in Biomedical Engineering, 51(1).

[7] Xu, Y., Liu, R., Yang, H., Qu, S., Qian, L., & Dai, Z. (2022). Enhancing Photodynamic Therapy Efficacy Against Cancer Metastasis by Ultrasound-Mediated Oxygen Microbubble Destruction to Boost Tumor-Targeted Delivery of Oxygen and Renal-Clearable Photosensitizer Micelles. ACS Applied Materials & Interfaces.

[8] Liu, R., Xu, Y., Zhang, N., Qu, S., Zeng, W., Li, R., & Dai, Z. (2022). Nanotechnology for Enhancing Medical Imaging. In: Gu, N. (eds) Nanomedicine. Micro/Nano Technologies. Springer, Singapore.

[9] Liu, W., Han, F., Qu, S., Yao, Y., Zhao, J., Akhtar, M. L., ... & Li, Y. (2018). MARVELD1 depletion leads to dysfunction of motor and cognition via regulating glia-dependent neuronal migration during brain development. Cell death & disease, 9(10), 1-17.

[10] Li, K^#., Qu, S^#., Chen, X., Wu, Q., & Shi, M. (2017). Promising targets for cancer immunotherapy: TLRs, RLRs, and STING-mediated innate immune pathways. International journal of molecular sciences, 18(2), 404.

獲獎情況：

北京大學優秀畢業生，2024