職稱：副研究員/碩導(dǎo)

學(xué)歷：博士研究生

QQ：250903611

電子郵件：ibptcc@fzu.edu.cn

研究方向：多功能水凝膠、抗菌材料、創(chuàng)面修復(fù)、腫瘤靶向/免疫治療、微納米控/緩釋載體等

招生方向：生物醫(yī)學(xué)工程（學(xué)碩）；生物工程（學(xué)碩）；生物技術(shù)與工程（生物與醫(yī)藥方向?qū)４T）

教育工作經(jīng)歷：

2023/09-至今，beat365在線體育官網(wǎng)，副研究員

2012/10-2023/09，beat365在線體育官網(wǎng)，助理研究員

2007/09-2012/07，南開大學(xué)，高分子化學(xué)與物理，碩博連讀，博士

2003/09-2007/07，遼寧大學(xué)，應(yīng)用化學(xué)，學(xué)士

教學(xué)簡介：

藥物傳遞系統(tǒng)，藥物生物技術(shù)，生物醫(yī)學(xué)工程綜合實(shí)驗(yàn)，功能高分子材料

科研簡介：

主要從事生物醫(yī)用材料研究領(lǐng)域的工作，研究涉及多功能水凝膠、創(chuàng)面修復(fù)、抗菌材料、腫瘤靶向/免疫治療、微納米控/緩釋載體等。目前主持多項(xiàng)課題，在Carbohydrate Polymers，ACS Applied Materials & Interfaces，Journal of Controlled Release，International Journal of Biological Macromolecules和Journal of Materials Chemistry B等期刊上發(fā)表SCI收錄的論文30余篇；以第一發(fā)明人獲得國家知識(shí)產(chǎn)權(quán)局授權(quán)發(fā)明專利4項(xiàng)。

人才稱號(hào)：福建省高層次人才（C類）

社會(huì)兼職：擔(dān)任Advanced Functional Material，ACS Applied Materials & Interfaces，Journal of Materials Chemistry B，International Journal of Biological Macromolecules等國際學(xué)術(shù)期刊審稿人

科研項(xiàng)目：

1. 福建省自然科學(xué)基金面上項(xiàng)目，多功能抗菌水凝膠調(diào)控炎性趨化因子協(xié)同LT-PTT促進(jìn)糖尿病足修復(fù)，主持。

2. 福建省衛(wèi)健委科技計(jì)劃中青年骨干人才培養(yǎng)項(xiàng)目，構(gòu)建tLyp1和HA修飾的石墨烯復(fù)合納米載藥體系用于肝癌光/化療研究，主持。

3. 上海智行環(huán)保科技有限公司橫向課題，用于水處理的多糖基水凝膠的制備，主持。

4. 國家自然科學(xué)基金青年項(xiàng)目，構(gòu)筑細(xì)菌微環(huán)境響應(yīng)性自愈合水凝膠多重促進(jìn)糖尿病足創(chuàng)面修復(fù)研究，主持。

5. 中國農(nóng)業(yè)科學(xué)院生物技術(shù)研究所橫向課題，用于基因遞送的水凝膠載體材料的制備，主持。

6. 天津大學(xué)-beat365在線體育官網(wǎng)自主創(chuàng)新基金，細(xì)菌微環(huán)境響應(yīng)性自愈合水凝膠的制備及其促進(jìn)糖尿病足創(chuàng)面修復(fù)機(jī)制研究，主持。

7. 福建省自然科學(xué)基金面上項(xiàng)目，多糖基原位凝膠的綠色制備及其用于順鉑控釋給藥系統(tǒng)的研究，主持。

8. 天津市生物醫(yī)學(xué)材料重點(diǎn)實(shí)驗(yàn)室開放課題，生物可降解納米復(fù)合材料作為順鉑藥物載體研究，主持。

9. beat365在線體育官網(wǎng)校人才基金項(xiàng)目，生物可降解納米復(fù)合材料作為順鉑藥物載體的研究，主持。

代表性論文：

1. Li Chen, Jinlan Luo, Jingyuan Zhang, Siyuan Wang, Yang Sun, Qinying Liu*, Cui Cheng*. Dual targeted nanoparticles for the codelivery of doxorubicin and siRNA cocktails to overcome ovarian cancer stem cells. J. Mol. Sci. 2023, 24(14), 11575.

2. Yuan Zhang, Wenjuan Chen, Wenjing Feng, Wenhong Fang, Xiao Han*, Cui Cheng*. Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation. Carbohydrate Polymers, 2023, 314, 120937.

3. Cui Cheng, Haowei Zhong, Yuan Zhang, Xiaoran Gao, Jianmin Wang*, Jingfeng Liu*, Xiao Han*. Bacterial responsive hydrogels based on quaternized chitosan and GQDs-ε-PL for chemo-photothermal synergistic anti-infection in diabetic wounds. International Journal of Biological Macromolecules, 2022, 210, 377–393.

4. Shujin Lin#, Chun Liu#*, Xiao Han*, Haowei Zhong, Cui Cheng*.Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy. International Journal of Molecular Sciences, 2021, 22(4): 1728.

5. Haowei Zhong#,  Xiaoran Gao#, Cui Cheng*, Chun Liu, Qiaowen Wang and Xiao Han*, The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems, Marine Drugs, 2020, 18(12), 658.

6. Shengcan Guan#, Ya Li#, Cui Cheng*, Xiaoran Gao, Xiaofeng Gu, Xiao Han*, Hanhui Ye*. Manufacture of pH- and HAase- responsive hydrogels with on-demand and continuous antibacterial activity for full-thickness wound healing. International Journal of Biological Macromolecules, 2020, 164, 2418-2431.

7. Li Chen, Wang, Siyuan Wang, Qinying Liu*, Zhihong Zhang, Shaofeng Lin, Qiuhong Zheng, Miaomiao Cheng, Yuying Li, Cui Cheng*. Reduction sensitive nanocarriers mPEG-g-γ-PGA/SSBPEI@siRNA for effective targeted delivery of survivin siRNA against NSCLC. Colloids and surfaces B: Biointerfaces, 2020, 193:111105. (if=4.389)

8. Cui Cheng, Zhihong Zhang, Siyuan Wang, Li Chen*, Qinying Liu*. Reduction sensitive CC9-PEG-SSBPEI/miR-148b nanoparticles: synthesis, characterization, targeting delivery and application for anti-metastasis. Colloids and Surfaces B: Biointerfaces, 2019: 110412.

9. Cui Cheng#*, Yabin Meng#, Zhihong Zhang, Ya Li, Qiqing Zhang*. Tumoral acidic pH-responsive cis-diaminodichloroplatinum-incorporated Cy5.5-PEG-g-A-HA nanoparticles for targeting delivery of CDDP against cervical cancer. ACS applied materials & interfaces, 2018, 10 (32), 26882-26892.

10. Cui Cheng#*, Yabin Meng#, Zhihong Zhang, Ya Li, Chun Liu, Qiqing Zhang*, pH responsible and fluorescent Cy5.5-PEG-g-A-HA/CDDP complex nanoparticles: synthesis, characterization, and application for targeted drug delivery, Journal of Materials Science: Materials in Medicine: 2019, 30 (6): 58.    

11. Cui Cheng#*, Xiuli Zhang#, Yabin Meng, Li Chen, Qiqing Zhang*. Development of a dual drug-loaded hydrogel delivery system for enhanced cancer therapy: in situ formation, degradation and synergistic antitumor efficiency. Journal of Materials Chemistry B, 2017, 5, 8487-8497.

12. Cui Cheng#*, Xiuli Zhang#, Yabin Meng, Zhihong Zhang, Jingdi Chen, Qiqing Zhang* Multiresponsive and biocompatible self-healing hydrogel: its facile synthesis in water, characterization and properties. Soft Matter, 2017, 13, 3003-3012.

13. Cui Cheng, Xiuli Zhang, Yabin Meng, Qiqing Zhang*, In situ forming polysaccharide based self-healing hydrogels for controlled release of cisplatin, Journal of Controlled Release, 2017, 259, e21-e22

14. Cui Cheng^#*, Dandan Xia^#, Xiuli Zhang, Li Chen, Qiqing Zhang*. Biocompatible poly (N-isopropylacrylamide)-g-carboxymethyl chitosan hydrogels as carriers for sustained release of cisplatin, Journal of Materials Science, 2015, 50(14): 4914-4925.

授權(quán)專利：

1. 程翠, 王思遠(yuǎn), 陳立, 劉沁穎, 還原性聚谷氨酸/聚乙烯亞胺/siRNA復(fù)合納米粒及制備與應(yīng)用, 2023.03.15, 中國, CN201911392627.5.

2. 程翠, 張秀麗, 游力軍, 王家斌, 張其清, 一種雙重載藥的自愈合水凝膠體系及其制備方法, 2020.05.08, 中國, CN201710205888.6.

3. 程翠, 張秀麗, 孟亞彬, 章志鴻, 陳景帝, 張其清, 一種基于昆布多糖的納米凝膠及其制備方法, 2019.01.22, 中國, CN201611121295.3.

4. 程翠, 夏丹丹, 張秀麗, 陳立, 張其清, 一種負(fù)載鉑類藥物的水凝膠體系及其制備方法, 2017.8.25, 中國, CN201510034796.7.

獲獎(jiǎng)情況：

2020年獲第十四屆福建省自然科學(xué)優(yōu)秀學(xué)術(shù)論文三等獎(jiǎng)

2018年獲得廈航獎(jiǎng)教金

歡迎對(duì)課題組研究方向感興趣的碩士生、本科生加入！