職稱：研究員

學歷：博士

電話：0591-22867972

電子郵件：cyuan@fzu.edu.cn

研究方向：化學生物學、生物化學與分子生物學

工作經(jīng)歷：

2016.6－        beat365在線體育官網(wǎng)beat365在線體育官網(wǎng)    

2010.6－2011.6   哈佛大學醫(yī)學院（訪問學者）                

2003.7－2016.6   中國科學院福建物質(zhì)結(jié)構研究所  

教育經(jīng)歷：

2005.3－2008.7   中國科學院福建物質(zhì)結(jié)構研究所   生物化學與分子生物學 博士

2000.9－2003.7   福建師范大學                   生物化學與分子生物學 碩士

教學簡介：

本科生課程《蛋白質(zhì)化學與工程》，研究生課程《蛋白質(zhì)結(jié)構與現(xiàn)代藥物開發(fā)》。指導學生獲得福建省研究生優(yōu)秀學位論文。

科研簡介：

主要從事蛋白的結(jié)構和功能研究，并基于結(jié)構進行多肽和蛋白類藥物的改造和評價。目前已發(fā)表SCI論文九十余篇，先后主持國家自然科學基金面上項目及福建省自然科學基金重點項目等。主要研究領域包括：

1、腫瘤遷移相關蛋白的結(jié)構和功能研究：幾乎90％癌癥病人的死亡是由于癌細胞的轉(zhuǎn)移性擴散引起。目前針對原發(fā)性腫瘤的治療卓有成效，但靶向腫瘤轉(zhuǎn)移方面的進展卻不盡人意。我們主要針對腫瘤遷移相關的一些蛋白如尿激酶受體系統(tǒng)和多種絲氨酸蛋白酶，及其與抑制劑的復合物進行X-射線晶體結(jié)構研究，并針對這些結(jié)構指導抑制劑和靶向彈頭的改造，以發(fā)展高效特異的腫瘤治療藥物。

2、血栓形成相關蛋白的結(jié)構和功能研究：人體保持血液處于正常流動狀態(tài)，主要依賴于凝血系統(tǒng)和纖溶系統(tǒng)處于一個動態(tài)平衡。病理條件下兩個系統(tǒng)的功能異常將導致出血或血栓形成。我們針對凝血和纖溶相關的一些蛋白如纖溶酶原激活物tPA、多種凝血因子及它們的調(diào)控蛋白PDI進行結(jié)構和功能的研究，并基于這些結(jié)構進行蛋白質(zhì)工程蛋白及抑制劑的設計和改造，以發(fā)展高效且無出血副作用的溶栓和抗血栓形成藥物。

3、光動力抗腫瘤和抗菌研究：光敏劑在特定波長的光激發(fā)下可產(chǎn)生具有生物毒性的單線態(tài)氧或者自由基，進而殺死細胞或微生物，可用于抗腫瘤和抗菌方面的治療。傳統(tǒng)的光敏劑存在靶向性差，水溶性不佳等問題。我們對光敏劑進行一系列的修飾和包裹，發(fā)展高靶向性光敏劑，用于抗腫瘤和耐藥菌的治療。

主持的科研項目：

1. 福建省自然科學基金重點項目，基于結(jié)構的溶栓劑改造及聯(lián)合用藥策略優(yōu)化（2022J02017），2022.08-2025.08

2. 國家自然科學基金面上項目，內(nèi)吞性膠原蛋白受體Endo180的結(jié)構研究（31570745），2016.01-2019.12

3. 國家自然科學基金面上項目，肝細胞生長因子激活物抑制劑1的結(jié)構研究（31170707），2012.1-2015.12

4. 國家自然科學基金面上項目，基質(zhì)降解相關蛋白的結(jié)構研究（30770429），2008.1-2010.12

近五年代表性論文：（^*為通訊作者）

(1) Xu, Y.; Hu, Y.; Wu, G.; Niu, L.; Fang, C.; Li, Y.; Jiang, L.; Yuan, C.^*; Huang, M.^* Specific inhibition on PAI-1 reduces the dose of Alteplase for ischemic stroke treatment. International Journal of Biological Macromolecules 2024, 257.

(2) Wang, G.; Li, J.; Zhang, W.; Jiang, L.; Mai, Y.; Chen, J.; Deng, L.; Chen, L.; Lin, Y.; Li, X.; Zou, H.; Xu, P.; Jiang, L.; Yuan, C.^*; Huang, M.^* A class of photosensitizer highly effective to control bacterial infection in plants even on rainy days with dim light. Dyes and Pigments 2024, 112065.

(3) Xu, Y.; Chen, D.; Liu, P.; Hu, Y.; Peng, S.; Chen, S.; Li, Y.; Lin, W.; Jiang, L.; Yuan, C.^*; Huang, M.^* A triple fusion tissue-type plasminogen activator (TriF-ΔtPA) enhanced thrombolysis in carotid embolism-induced stroke model. International Journal of Pharmaceutics 2023, 637, 122878.

(4) Liu, D.; Jiang, L.; Chen, J.; Chen, Z.; Yuan, C.^*; Lin, D. ^*; Huang, M.^* Monomer and Oligomer Transition of Zinc Phthalocyanine Is Key for Photobleaching in Photodynamic Therapy. Molecules 2023, 28 (12).

(5) Liao, X.; Ji, P.; Chi, K.; Chen, X.; Zhou, Y.; Chen, S.; Cheng, Y.; Flaumenhaft, R.; Yuan, C.^*; Huang, M.^* Enhanced inhibition of protein disulfide isomerase and anti-thrombotic activity of a rutin derivative: rutin:Zn complex. RSC Advances 2023, 13 (17), 11464-11471.

(6) Li, H.; Wang, Z.; Yu, S.; Chen, S.; Zhou, Y.; Qu, Y.; Xu, P.; Jiang, L.; Yuan, C.^*; Huang, M.^* Albumin-based drug carrier targeting urokinase receptor for cancer therapy. International Journal of Pharmaceutics 2023, 634, 122636.

(7) Yu, S.; Sui, Y.; Wang, J.; Li, Y.; Li, H.; Cao, Y.; Chen, L.; Jiang, L.; Yuan, C.^*; Huang, M.^* Crystal structure and cellular functions of uPAR dimer. Nature Communications 2022, 13 (1), 1665.

(8) Wang, G.; Yang, L.; Jiang, L.; Chen, J.; Jing, Q.; Mai, Y.; Deng, L.; Lin, Y.; Chen, L.; Chen, Z.; Xu, P.; Jiang, L.; Yuan, C.^*; Huang, M.^* A new class of quaternary ammonium compounds as potent and environmental friendly disinfectants. Journal of Cleaner Production 2022, 379, 134632.

(9) Liao, X.; Zhuang, X.; Liang, C.; Li, J.; Flaumenhaft, R.; Yuan, C.^*; Huang, M.^* Flavonoids as Protein Disulfide Isomerase Inhibitors: Key Molecular and Structural Features for the Interaction. Journal of Agricultural and Food Chemistry 2022, 70 (14), 4475-4483.

(10) Liang, C.; Flaumenhaft, R.; Yuan, C.^*; Huang, M.^* Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development. Drug Discovery Today 2022, 27 (2), 626-635.

(11) Liang, C.; Cai, M.; Xu, Y.; Fu, W.; Wu, J.; Liu, Y.; Liao, X.; Ning, J.; Li, J.; Huang, M.^*; Yuan, C.^* Identification of Antithrombotic Natural Products Targeting the Major Substrate Binding Pocket of Protein Disulfide Isomerase. Journal of Natural Products 2022, 85 (5), 1332-1339.

(12) Huang, Z.; Lin, H.; Yu, S.; Li, H.; Zhou, Y.; Cheng, Y.; Chen, S.; Yuan, C.^*; Huang, M.^* A versatile insertion point on albumin to accommodate peptides and maintain their activities. International Journal of Biological Macromolecules 2022, 205, 49-54.

(13) Chen, S.^#; Yuan, C.^#; Jiang, L.; Luo, Z.^*; Huang, M.^* Crystallographic analysis of interaction between cisplatin and human serum albumin: Effect of fatty acid. International Journal of Biological Macromolecules 2022, 216, 172-178.

(14) Chen, D.; Liu, Y.; Liu, P.; Zhou, Y.; Jiang, L.; Yuan, C.^*; Huang, M.^* Orally delivered rutin in lipid-based nano-formulation exerts strong antithrombotic effects by protein disulfide isomerase inhibition. Drug Delivery 2022, 29 (1), 1824-1835.

(15) Zhang, D.; Chen, J.; Jing, Q.; Chen, Z.; Ullah, A.; Jiang, L.; Zheng, K.; Yuan, C.^*; Huang, M.^* Development of a Potent Antimicrobial Peptide With Photodynamic Activity. Frontiers in Microbiology 2021, 12, 624465.

(16) Yuan, C.; Guo, Z.; Yu, S.; Jiang, L. ^*; Huang, M.^* Development of inhibitors for uPAR: blocking the interaction of uPAR with its partners. Drug Discovery Today 2021, 26 (4), 1076-1085.

(17) Yu, S.; Sun, G.; Sui, Y.; Li, H.; Mai, Y.; Wang, G.; Zhang, N.; Bi, Y.; Gao, G. F.; Xu, P.; Jiang, L.; Yuan, C.^*; Yang, Y.^*; Huang, M.^* Potent inhibition of Severe Acute Respiratory Syndrome Coronavirus 2 by photosensitizers compounds. Dyes and Pigments 2021, 194, 109570.

(18) Liang, C.; Flaumenhaft, R.; Yuan, C.^*; Huang, M.^* Vascular thiol isomerases: Structures, regulatory mechanisms, and inhibitor development. Drug discovery today 2021.

(19) Li, L.; Huang, M.^*; Shen, J.; Wang, Y.; Wang, R.; Yuan, C.^*; Jiang, L.; Huang, M. Serum Levels of Soluble Platelet Endothelial Cell Adhesion Molecule 1 in COVID-19 Patients Are Associated With Disease Severity. The Journal of Infectious Diseases 2021, 223 (1), 178-179.

(20) Jiang, L.; Yuan, C.^*; Huang, M.^* A general strategy to inhibit serine protease by targeting its autolysis loop. The FASEB Journal 2021, 35 (2), e21259.

(21) Jiang, L.; Jiang, Y.; Li, L.; Zheng, K.; Yu, S.; Li, J.; Yuan, C.^*; Huang, M.^* A supramolecular nanocarrier for efficient cancer imaging and therapy by targeting at matriptase. Journal of Controlled Release 2021, 334, 153-163.

(22) Chen, S.; Chen, D.; Liu, Y.; Xu, Y.; Lin, H.; Cheng, Y.; Li, J.; Meng, C.; Liang, M.; Yuan, C.^*; Huang, M.^* Enhanced clot lysis by a single point mutation in a reteplase variant. British Journal of Haematology 2021, 196 (4), 1076-1085.

(23) Li, L.; Chen, D.; Zheng, K.; Jiang, L.; Dai, T.; Yang, L.; Jiang, L.; Chen, Z.; Yuan, C.^*; Huang, M.^* Enhanced Antitumor Efficacy and Imaging Application of Photosensitizer-Formulated Paclitaxel. ACS Applied Materials & Interfaces 2020, 12 (4), 4221-4230.

(24) Jiang, Y.; Lin, L.; Chen, S.; Jiang, L.; Kriegbaum, M. C.; Grdsvoll, H.; Hansen, L. V.; Li, J.; Ploug, M.; Yuan, C.^*; Huang, M.^* Crystal Structures of Human C4.4A Reveal the Unique Association of Ly6/uPAR/alpha-neurotoxin Domain. International Journal of Biological Sciences 2020, 16 (6), 981-993.

(25) Jiang, L.; Liu, Y.; Xu, X.; Su, D.; Zou, H.; Liu, J.; Yuan, C.^*; Huang, M.^* Inhibition of the Citrus Canker Pathogen Using a Photosensitizer Assisted by Sunlight Irradiation. Frontiers in Microbiology 2020, 11, 571691.

(26) 許燕艷; 陳珊莉; 陳丹; 彭雙周; 程媛; 李金宇; 李永坤; 江龍光; 袁彩^*; 黃明東^*. 缺血性腦卒中溶栓藥物研究進展. 生物工程學報 2020, 36 (10), 2029-2039.

(27) 梁程輝; 陳丹; 廖馨源; 江龍光; 袁彩^*; 黃明東^*. 蛋白質(zhì)二硫鍵異構酶的結(jié)構及抑制劑研究進展. 生物化學與生物物理進展 2020, 47 (07), 595-606.

(28) Shang, L.; Xue, G.; Gong, L.; Zhang, Y.; Peng, S.; Yuan, C.^*; Huang, M.^* A novel ELISA for the detection of active form of plasminogen activator inhibitor-1 based on a highly specific trapping agent. Analytica Chimica Acta 2019, 1053, 98-104.

(29) Liu, M.; Lin, L.^*; Hoyer-Hansen, G.; Ploug, M.; Li, H.; Jiang, L.; Yuan, C.^*; Li, J.; Huang, M.^* Crystal structure of the unoccupied murine urokinase-type plasminogen activator receptor (uPAR) reveals a tightly packed DII-DIII unit. Febs Letters 2019, 593 (11), 1236-1247.

(30) Li, R.; Liang, C.; Jiang, L.; Yuan, C.^*; Huang, M.^* Structural determination of group A Streptococcal surface dehydrogenase and characterization of its interaction with urokinase-type plasminogen activator receptor. Biochemical and Biophysical Research Communications 2019, 510 (4), 539-544.

其他

研究生招生專業(yè)：生物醫(yī)學工程、生物工程、生物技術與工程；歡迎有志從事科研工作的碩士生報考我們課題組。

課題組介紹：http://fmerc.fzu.edu.cn/html/rcdw/hmdktz/1.html