職稱：教授/博導(dǎo)

學(xué)歷：博士研究生

電話：

電子郵件： zhcen7917@fzu.edu.cn

研究方向：腫瘤分子生物學(xué)

教育工作經(jīng)歷：

1997.09-2001.07   廈門大學(xué)，學(xué)士

2001.09-2006.07   清華大學(xué)，博士

2006-12-2008.11  美國(guó)匹茲堡大學(xué)醫(yī)學(xué)中心 博士后

2008.11-2019.4     美國(guó)羅格斯大學(xué)新澤西癌癥研究所 博士后

2019.11至今          beat365在線體育官網(wǎng) “閩江學(xué)者”特聘教授

教學(xué)簡(jiǎn)介：

科研簡(jiǎn)介：

研究方向主要集中在抑癌基因基因p53和腫瘤代謝重編程方面。抑癌基因p53在維持基因組穩(wěn)定以及抑制腫瘤發(fā)生方面有著重要作用。p53是腫瘤中突變頻率最高的基因，超過(guò)50%的腫瘤包含p53突變，80%以上的腫瘤中p53信號(hào)通路功能異常。作為一個(gè)轉(zhuǎn)錄因子，p53蛋白能被細(xì)胞內(nèi)外各種干擾，包括DNA損傷、缺氧、核糖體合成受阻乃至原癌基因激活等激活，從而進(jìn)一步選擇性的激活其下游的各種目的基因，引起諸如細(xì)胞凋亡、細(xì)胞周期阻滯以及細(xì)胞衰亡等過(guò)程，避免細(xì)胞癌化。代表性成果包括：

1）發(fā)現(xiàn)了兩個(gè)對(duì)腫瘤代謝有重要影響的p53目的基因GLS2和Parkin (PNAS, 2010& 2011, IF:9.504)，并在此基礎(chǔ)上進(jìn)一步分析了它們?cè)谀[瘤的作用和分子機(jī)制，闡明了(a) GLS2通過(guò)與Rho GTP酶Rac1的結(jié)合降低Rac1活性，抑制由Rac1活性升高引起的腫瘤生長(zhǎng)與轉(zhuǎn)移 (Elife, 2016，IF: 7.616)；(b) Parkin作為一個(gè)E3泛素連接酶，能夠結(jié)合并機(jī)制降解HIF-1α，從而抑制由HIF-1α引起的腫瘤生長(zhǎng)與轉(zhuǎn)移為相關(guān)腫瘤的治療提供了新的策略（Nature Communication, 2017, IF: 12.353）。

2）首次報(bào)道了腫瘤相關(guān)p53突變能夠通過(guò)改變RhoA活性促進(jìn)葡萄糖轉(zhuǎn)運(yùn)蛋白GLUT1向細(xì)胞膜上轉(zhuǎn)移，從而增加葡萄糖的吸收和糖酵解，進(jìn)而促進(jìn)腫瘤生長(zhǎng)，為含有p53突變的腫瘤治療提供了新思路（Nature Communication, 2013, IF: 12.353）。

3) 抑癌基因CUL3能夠與ATP-檸檬酸裂解酶（ACLY）結(jié)合，導(dǎo)致其泛素化降解，從而降低細(xì)胞脂類合成水平，抑制腫瘤的生長(zhǎng)。因此，在CUL3突變或缺失的肺癌中，使用ACLY抑制劑能夠有效的減緩肺癌的生長(zhǎng) （Gene & Development, 2016, IF: 9.462）。

社會(huì)兼職：

科研項(xiàng)目：

1. Parkin調(diào)控腫瘤代謝重編程及鐵死亡的新分子機(jī)制研究（國(guó)家自然科學(xué)基金面上項(xiàng)目2021-2024）

2. 閩江學(xué)者啟動(dòng)基金項(xiàng)目 2020-2023

3. GLS2, a Novel p53 target gene, in liver tumor（美國(guó)新澤西癌癥研究委員會(huì)博士后項(xiàng)目2009-2011）

代表性論文：

1. Juan Liu*, Cen Zhang*, Hao Wu, Xiao-Xin Sun, Yanchen Li, Shan Huang, Xuetian Yue, Shou-En Lu, Zhiyuan Shen, Xiaoyang Su, Eileen White, Bruce G Haffty, Wenwei Hu,  Zhaohui Feng. Parkin ubiquitinates phosphoglycerate dehydrogenase to suppress serine synthesis and tumor progression. J Clin Invest. 2020, 130:3253-3269. (*: co-first author) (IF:12.772)

2. Juan Liu*, Cen Zhang*, Yuhan Zhao, Xuetian Yue, Hao Wu, Shan Huang, James Chen, Kyle Tomsky, Haiyang Xie, Christen A. Khella, Michael L. Gatza,  Dajing Xia,  Jimin Gao, Bruce G Haffty, Wenwei Hu,  Zhaohui Feng. Parkin targets HIF-1α for ubiquitination and degradation to inhibit tumor progression. Nat Commun, 2017, 8:1823. (*: co-first author) (IF:12.353)

3. Xuetian Yue, Cen Zhang, Yuhan Zhao, Juan Liu, Alan W. Lin, Victor M. Tan, Justin M. Drake, Lianxin Liu, Michael N. Boateng, Jun Li, Zhaohui Feng, Wenwei Hu. Gain-of-function mutant p53 activates Proof Only small GTPase Rac1 through SUMOylation to promote tumor progression. Genes Dev, 2017, 31: 1641-1654.(IF:9.462)

4. Cen Zhang*, Juan Liu*, Grace Huang, Yuhan Zhao, Xuetian Yue, Hao Wu, Jun Li, Junlan Zhu, Zhiyuan Shen, Bruce G Haffty, Wenwei Hu, Zhaohui Feng. Cullin3-KLHL25 ubiquitin ligase targets ACLY for degradation to inhibit lipid synthesis and tumor progression. Genes Dev, 2016, 30:1956-70. (*: co-first author) (IF:9.462)

5. Cen Zhang*, Juan Liu*, Yuhan Zhao, Xuetian Yue, Yu Zhu, Xiaolong Wang, Hao Wu, Felix Blanco, Shaohua Li, Gyan Bhanot, Bruce G Haffty, Wenwei Hu, Zhaohui Feng. Glutaminase 2 is a novel negative regulator of small GTPase Rac1 and mediates p53 function in suppressing metastasis. Elife, 2016, 5:e10727. (*: co-first author) (IF:7.616)

6. Xuetian Yue, Yuhan Zhao, Cen Zhang, Jun Li, Zhen Liu, Juan Liu, Wenwei Hu. Leukemia inhibitory factor promotes EMT through STAT3-dependent miR-21 induction. Oncotarget, 2016, 7:3777-3790.(IF:5.168)

7. Yuhan Zhao, Cen Zhang, Xuetian Yue, Xiaoyan Li, Juan Liu, Haiyang Yu, VA Belyi, Qifeng Yang, Zhaohui Feng, Wenwei Hu. Pontin, a new mutant p53-binding protein, promotes gain-of-function of mutant p53. Cell Death Differ, 2014, 22:1824-1836. (IF:8.000)

8. Juan Liu*, Cen Zhang*, Xiaolong Wang, P Ly, V Belyi, Zijun Y Xu-Monette, Ken H Young, Wenwei Hu, Zhaohui Feng. E3 ubiquitin ligase TRIM32 negatively regulates tumor suppressor p53 to promote tumorigenesis. Cell Death Differ, 2014, 21:1792-1804. (*: co-first author) (IF:8.000)

9. Cen Zhang, Juan Liu, Yingjian Liang, Rui Wu, Yuhan Zhao, Xuehui Hong, Meihua Lin , Haiyang Yu, Lianxin Liu, Arnold J. Levine, Wenwei Hu, Zhaohui Feng. Tumor-Associated Mutant p53 Drives the Warburg Effect. Nat. Commun., 2013, 4:2935.(IF:12.353)

10. Zhaohui Feng, Lianxin Liu, Cen Zhang, Tongsen Zheng, Jiabei Wang, Meihua Lin, Yuhan Zhao, Xiaowen Wang, Arnold J. Levined and Wenwei Hu. Chronic restraint stress attenuates p53 function and promotes tumorigenesis. Proc Natl Acad Sci U S A, 2012, 109: 7013-7018. (IF:9.504)

11. Cen Zhang, Meihua Lin, Rui Wu, Xiaowen Wang, Bo Yang, Arnold J. Levine, Wenwei Hu and Zhaohui Feng. Parkin, a p53 target gene, mediates the role of p53 in glucose metabolism and the Warburg effect.Proc Natl Acad Sci U S A, 2011, 108:16259-64.(IF:9.504)

12. Wenwei Hu, Chang S. Chan, Rui Wu, Cen Zhang, Yvonne Sun, Jun S. Song, Laura H. Tang, Arnold J. Levine and Zhaohui Feng. Negative Regulation of Tumor Suppressor p53 by microRNA miR-504. Mol Cell, 2010, 38:689-699.(IF:14.248)

13. Wenwei Hu, Cen Zhang, Rui Wu, Yvonne Sun, Arnold J. Levine and Zhaohui Feng. Glutaminase 2 is a novel p53 target gene regulating energy metabolism. Proc. Natl. Acad. Sci. USA, 2010, 107:7455-7460.(IF:9.504)

獲獎(jiǎng)情況：

  2009年2014年 美國(guó)新澤西癌癥研究委員會(huì) 杰出青年科學(xué)家Gallo Award