職稱：副研究員/碩導

學歷：博士研究生

QQ：250903611

電子郵件：ibptcc@fzu.edu.cn

研究方向：多功能水凝膠、抗菌材料、創面修復、腫瘤靶向/免疫治療、微納米控/緩釋載體等

招生方向：生物醫學工程（學碩）；生物工程（學碩）；生物技術與工程（生物與醫藥方向專碩）

教育工作經歷：

2023/09-至今，beat365在線體育官網，副研究員

2012/10-2023/09，beat365在線體育官網，助理研究員

2007/09-2012/07，南開大學，高分子化學與物理，碩博連讀，博士

2003/09-2007/07，遼寧大學，應用化學，學士

教學簡介：

藥物傳遞系統，藥物生物技術，生物醫學工程綜合實驗，功能高分子材料

科研簡介：

主要從事生物醫用材料研究領域的工作，研究涉及多功能水凝膠、創面修復、抗菌材料、腫瘤靶向/免疫治療、微納米控/緩釋載體等。目前主持多項課題，在Carbohydrate Polymers，ACS Applied Materials & Interfaces，Journal of Controlled Release，International Journal of Biological Macromolecules和Journal of Materials Chemistry B等期刊上發表SCI收錄的論文30余篇；以第一發明人獲得國家知識產權局授權發明專利4項。

人才稱號：福建省高層次人才（C類）

社會兼職：擔任Advanced Functional Material，ACS Applied Materials & Interfaces，Journal of Materials Chemistry B，International Journal of Biological Macromolecules等國際學術期刊審稿人

科研項目：

1. 福建省自然科學基金面上項目，多功能抗菌水凝膠調控炎性趨化因子協同LT-PTT促進糖尿病足修復，主持。

2. 福建省衛健委科技計劃中青年骨干人才培養項目，構建tLyp1和HA修飾的石墨烯復合納米載藥體系用于肝癌光/化療研究，主持。

3. 上海智行環保科技有限公司橫向課題，用于水處理的多糖基水凝膠的制備，主持。

4. 國家自然科學基金青年項目，構筑細菌微環境響應性自愈合水凝膠多重促進糖尿病足創面修復研究，主持。

5. 中國農業科學院生物技術研究所橫向課題，用于基因遞送的水凝膠載體材料的制備，主持。

6. 天津大學-beat365在線體育官網自主創新基金，細菌微環境響應性自愈合水凝膠的制備及其促進糖尿病足創面修復機制研究，主持。

7. 福建省自然科學基金面上項目，多糖基原位凝膠的綠色制備及其用于順鉑控釋給藥系統的研究，主持。

8. 天津市生物醫學材料重點實驗室開放課題，生物可降解納米復合材料作為順鉑藥物載體研究，主持。

9. beat365在線體育官網校人才基金項目，生物可降解納米復合材料作為順鉑藥物載體的研究，主持。

代表性論文：

1. Li Chen, Jinlan Luo, Jingyuan Zhang, Siyuan Wang, Yang Sun, Qinying Liu*, Cui Cheng*. Dual targeted nanoparticles for the codelivery of doxorubicin and siRNA cocktails to overcome ovarian cancer stem cells. J. Mol. Sci. 2023, 24(14), 11575.

2. Yuan Zhang, Wenjuan Chen, Wenjing Feng, Wenhong Fang, Xiao Han*, Cui Cheng*. Multifunctional chondroitin sulfate based hydrogels for promoting infected diabetic wounds healing by chemo-photothermal antibacterial and cytokine modulation. Carbohydrate Polymers, 2023, 314, 120937.

3. Cui Cheng, Haowei Zhong, Yuan Zhang, Xiaoran Gao, Jianmin Wang*, Jingfeng Liu*, Xiao Han*. Bacterial responsive hydrogels based on quaternized chitosan and GQDs-ε-PL for chemo-photothermal synergistic anti-infection in diabetic wounds. International Journal of Biological Macromolecules, 2022, 210, 377–393.

4. Shujin Lin#, Chun Liu#*, Xiao Han*, Haowei Zhong, Cui Cheng*.Viral Nanoparticle System: An Effective Platform for Photodynamic Therapy. International Journal of Molecular Sciences, 2021, 22(4): 1728.

5. Haowei Zhong#,  Xiaoran Gao#, Cui Cheng*, Chun Liu, Qiaowen Wang and Xiao Han*, The Structural Characteristics of Seaweed Polysaccharides and Their Application in Gel Drug Delivery Systems, Marine Drugs, 2020, 18(12), 658.

6. Shengcan Guan#, Ya Li#, Cui Cheng*, Xiaoran Gao, Xiaofeng Gu, Xiao Han*, Hanhui Ye*. Manufacture of pH- and HAase- responsive hydrogels with on-demand and continuous antibacterial activity for full-thickness wound healing. International Journal of Biological Macromolecules, 2020, 164, 2418-2431.

7. Li Chen, Wang, Siyuan Wang, Qinying Liu*, Zhihong Zhang, Shaofeng Lin, Qiuhong Zheng, Miaomiao Cheng, Yuying Li, Cui Cheng*. Reduction sensitive nanocarriers mPEG-g-γ-PGA/SSBPEI@siRNA for effective targeted delivery of survivin siRNA against NSCLC. Colloids and surfaces B: Biointerfaces, 2020, 193:111105. (if=4.389)

8. Cui Cheng, Zhihong Zhang, Siyuan Wang, Li Chen*, Qinying Liu*. Reduction sensitive CC9-PEG-SSBPEI/miR-148b nanoparticles: synthesis, characterization, targeting delivery and application for anti-metastasis. Colloids and Surfaces B: Biointerfaces, 2019: 110412.

9. Cui Cheng#*, Yabin Meng#, Zhihong Zhang, Ya Li, Qiqing Zhang*. Tumoral acidic pH-responsive cis-diaminodichloroplatinum-incorporated Cy5.5-PEG-g-A-HA nanoparticles for targeting delivery of CDDP against cervical cancer. ACS applied materials & interfaces, 2018, 10 (32), 26882-26892.

10. Cui Cheng#*, Yabin Meng#, Zhihong Zhang, Ya Li, Chun Liu, Qiqing Zhang*, pH responsible and fluorescent Cy5.5-PEG-g-A-HA/CDDP complex nanoparticles: synthesis, characterization, and application for targeted drug delivery, Journal of Materials Science: Materials in Medicine: 2019, 30 (6): 58.    

11. Cui Cheng#*, Xiuli Zhang#, Yabin Meng, Li Chen, Qiqing Zhang*. Development of a dual drug-loaded hydrogel delivery system for enhanced cancer therapy: in situ formation, degradation and synergistic antitumor efficiency. Journal of Materials Chemistry B, 2017, 5, 8487-8497.

12. Cui Cheng#*, Xiuli Zhang#, Yabin Meng, Zhihong Zhang, Jingdi Chen, Qiqing Zhang* Multiresponsive and biocompatible self-healing hydrogel: its facile synthesis in water, characterization and properties. Soft Matter, 2017, 13, 3003-3012.

13. Cui Cheng, Xiuli Zhang, Yabin Meng, Qiqing Zhang*, In situ forming polysaccharide based self-healing hydrogels for controlled release of cisplatin, Journal of Controlled Release, 2017, 259, e21-e22

14. Cui Cheng^#*, Dandan Xia^#, Xiuli Zhang, Li Chen, Qiqing Zhang*. Biocompatible poly (N-isopropylacrylamide)-g-carboxymethyl chitosan hydrogels as carriers for sustained release of cisplatin, Journal of Materials Science, 2015, 50(14): 4914-4925.

授權專利：

1. 程翠, 王思遠, 陳立, 劉沁穎, 還原性聚谷氨酸/聚乙烯亞胺/siRNA復合納米粒及制備與應用, 2023.03.15, 中國, CN201911392627.5.

2. 程翠, 張秀麗, 游力軍, 王家斌, 張其清, 一種雙重載藥的自愈合水凝膠體系及其制備方法, 2020.05.08, 中國, CN201710205888.6.

3. 程翠, 張秀麗, 孟亞彬, 章志鴻, 陳景帝, 張其清, 一種基于昆布多糖的納米凝膠及其制備方法, 2019.01.22, 中國, CN201611121295.3.

4. 程翠, 夏丹丹, 張秀麗, 陳立, 張其清, 一種負載鉑類藥物的水凝膠體系及其制備方法, 2017.8.25, 中國, CN201510034796.7.

獲獎情況：

2020年獲第十四屆福建省自然科學優秀學術論文三等獎

2018年獲得廈航獎教金

歡迎對課題組研究方向感興趣的碩士生、本科生加入！