職稱：教授，博士生導師

學歷：博士研究生

電子郵件： shixa@fzu.edu.cn

一、研究方向：

1. 生物材料與組織工程

2. 合成生物技術(shù)與生物催化

3. 酶定向進化與改造

4. 海洋生物技術(shù)

二、博士生招生專業(yè)：

1. 生物醫(yī)學工程（學術(shù)型）

2. 生物與醫(yī)藥（專業(yè)學位型）

三、碩士生招生專業(yè)：

1. 生物工程（學術(shù)型）

2. 生物醫(yī)學工程（學術(shù)型）

3. 生物技術(shù)與工程（專業(yè)學位型）

教育工作經(jīng)歷：

1994.8至今：beat365在線體育官網(wǎng)beat365在線體育官網(wǎng)，助教、講師、副教授、教授

2015.1-2016.1：美國農(nóng)業(yè)部東部研究中心（ERRC）訪學

2002.9-2009.3，華南理工大學，生物化工，博士

1998.9-2001.3，beat365在線體育官網(wǎng)，化學工程，碩士

1990.9-1994.7，華東理工大學，生物化工，本科

教學簡介：

講授本科生課程：《合成生物學》、《微生物遺傳育種學》

講授研究生課程：《生物催化與轉(zhuǎn)化工程》、《生物催化原理與應用》

參編教材：《藥物生物技術(shù)》（高等教育出版社）、《微生物工程》（科學出版社）

科研簡介：

主持福建省科技重大專項（經(jīng)費450萬元）、國家海洋公益專項子任務（276萬元）等國家級和省級縱向課題；作為第二負責人主持國家海洋公益專項（2351萬元）；主持硫酸軟骨素生產(chǎn)技術(shù)（423萬元）及生物敷料生產(chǎn)技術(shù)（270萬元）等橫向課題。在Advanced Functional Materials（IF18.5/Q1）等期刊上發(fā)表研究論文150余篇，授權(quán)發(fā)明專利30余件，相關(guān)研究成果已在7家企業(yè)應用，獲5項福建省科學技術(shù)獎。

社會兼職：

中國微生物學會會員、美國化學會（ACS）會員、美國癌癥研究協(xié)會（AACR）會員、國際仿生工程學會會員、福建省生物工程學會常務理事、福建省生物醫(yī)學工程學會常務理事、福建省腫瘤生物治療重點實驗室學術(shù)委員會委員、福建省產(chǎn)業(yè)計量技術(shù)委員會委員；

為Nano-Micro Letters（IF31.6）、Advanced Materials（IF27.4）、Advanced Functional Materials（IF18.5）等期刊審稿人。

科研項目：

主持經(jīng)費超過100萬元項目

1. 福建省科技重大專項“海洋生物資源高值化利用技術(shù)研究”（450萬元）

2. 國家海洋公益專項子任務“β-葡萄糖苷酶分離提取和產(chǎn)業(yè)化工藝的關(guān)鍵技術(shù)應用性研究開發(fā)”（276萬元）

3. 橫向項目“海洋硫酸軟骨素生產(chǎn)技術(shù)”（423萬元）

4. 橫向項目“用于皮膚修復的生物敷料生產(chǎn)技術(shù)”（270萬元）

5. 橫向項目“干細胞醫(yī)療器械關(guān)鍵技術(shù)研發(fā)”（100萬元）

6. 國家海洋公益性行業(yè)科研專項“藥源生物活性物質(zhì)產(chǎn)業(yè)化應用關(guān)鍵技術(shù)研究和示范”（2351萬元，第二負責人及后期實際負責人）。

代表性論文：（#為第一作者，*為通訊作者）

1. Y Lv, F Cai, X Zhao, X Zhu, F Wei, Y Zheng, X Shi*, J Yang*, Bioinspired microstructured Janus bioadhesive for the prevention of abdominal and intrauterine adhesions. Advanced Functional Materials 2024, 2314402

2. X Zhao, Y Zhuang, Y Cao, F Cai, Y Lv, Y Zheng, J Yang*, X Shi*, Electrospun biomimetic periosteum capable of controlled release of multiple agents for programmed promoting bone regeneration, Advanced Healthcare Materials 2024, 202303134.

3. Mingmao Chen, Yulei Fu, Yan Liu,* Baihe Zhang, Xiaorong Song, Xinchun Chen, Zhengjia Zhu, Hang Gao, Jianmin Yang, and Xianai Shi*, NIR-Light-Triggered Mild-Temperature Hyperthermia to Overcome the Cascade Cisplatin Resistance for Improved Resistant Tumor Therapy, Advanced Healthcare Materials 2024, 202303667.

4. J Yang, Y He, Z Li, X Yang, Y Gao, M Chen, Y Zheng, S Mao*, X Shi*, Intelligent wound dressing for simultaneous in situ detection and elimination of pathogenic bacteria. Acta Biomaterialia 2024, 174, 177–190.

5. Yicheng Lv, Liang Li, Jingyuan Zhang, Jingsi Li, Fengying Cai, Yufeng Huang, Xiaomeng Li, Yunquan Zheng, Xianai Shi,* and Jianmin Yang*, Visible-Light Cross-Linkable Multifunctional Hydrogels Loaded with Exosomes Facilitate Full-Thickness Skin Defect Wound Healing through Participating in the Entire Healing Process. ACS Applied Materials & Interfaces 2024, 16, 25923-25937.

6. Jianmin Yang*, Fengying Cai, Yicheng Lv, Ting Jiang, Xingkai Zhao, Xueli Hu, Yunquan Zheng, Xianai Shi,* Chitosan nonwoven fabric composited calcium alginate and adenosine diphosphate as a hemostatic bandage for acute bleeding wounds. International Journal of Biological Macromolecules 2024, 257, 128561.

7. Wenqiang Liao, Siqi Xiao, Jianmin Yang, Xianai Shi, Yunquan Zheng,* Multifunctional nanogel based on carboxymethyl cellulose interfering with cellular redox homeostasis enhances phycocyanobilin photodynamic therapy. Carbohydrate Polymers 2024, 323, 121416.

8. Li Zhao, Wenqiang Liao, Guibin Lin, Jianmin Yang, Xianai Shi, Yunquan Zheng,* Rubropunctatin-silver composite nanoliposomes for eradicating Helicobacter pylori in vitro and in vivo. International Journal of Pharmaceutics 2024, 649, 123655.

9. Yongjian Cao, Haijie Zhang, Mengjie Qiu, Yunquan Zheng,* Xianai Shi, Jianmin Yang,* Biomimetic injectable and bilayered hydrogel scaffold based on collagen and chondroitin sulfate for the repair of osteochondral defects. International Journal of Biological Macromolecules 2024, 257, 128593.

10. Mengjie Qiu, Yating He, Haijie Zhang, Yunquan Zheng,* Xianai Shi, Jianmin Yang, Platelet-Rich Plasma (PRP) Based on Simple and Efficient Integrated Preparation Precises Quantitatively for Skin Wound Repair. International Journal of Molecular Sciences 2024, 25, 9340.

11. Haijie Zhang, Yinbo Wu, Mengjie Qiu, Yunquan Zheng,* Li Chen, Xianai Shi, Jianmin Yang, Qiong Lin, Jianqing Lin,* Lotus leaf Nuciferine improves sleep and reduces the low neuronal activity and brain tissue abnormalities associated with insomnia. Food Bioscience 2024, 62, 105345.

12. Mingming Zhao, Jeongwon Kim, Jiayan Jiao, Yelin Lim, Xianai Shi, Shaobin Guo*, Jongmin Kim*, Construction of multilayered gene circuits using de-novo-designed synthetic transcriptional regulators in cell-free systems, Journal of Biological Engineering 2024, 18, 64.

13. Y Lv, F Cai, Y He, L Li, Y Huang, J Yang*, Y Zheng, X Shi*, Multi-crosslinked hydrogels with strong wet adhesion, self-healing, antibacterial property, reactive oxygen species scavenging activity, and on-demand removability for seawater-immersed wound healing, Acta Biomaterialia 2023, 159: 95?110.

14. Z Fang#, Y Lv#, H Zhang#, Y He, H Gao, C Chen, D Wang, P Chen, S Tang, J Li, Z Qiu, X Shi, L Chen*, J Yang*, X Chen*, A multifunctional hydrogel loaded with two nanoagents improves the pathological microenvironment associated with radiation combined with skin wounds, Acta Biomaterialia 2023, 159: 111?127.

15. W Wang, J Dai, Y Huang, X Li, J Yang*, Y Zheng, X Shi*, Extracellular matrix mimicking dynamic interpenetrating network hydrogel for skin tissue engineering, Chemical Engineering Journal 2023, 457: 141362.

16. F Cai#, Y Ren#, J Dai, J Yang*, X Shi*, Effects of various cell surface engineering reactions on the biological behavior of mammalian cells, Macromolecular Bioscience 2023, 23, 2200379.

17. J Li, X Sun, J Dai, J Yang*, Liang Li, Z Zhang, J Guo, S Bai*, Y Zheng, X Shi*, Biomimetic multifunctional hybrid sponge via enzymatic cross-linking to accelerate infected burn wound healing, International Journal of Biological Macromolecules 2023, 225, 90–102.

18. S Ning, C Wang, L Zhao, Y Huang, J Yang, X Shi, Y Zheng*, Lecithinitosan nanoparticle drug carrier improves anti-tumor efficacy of Monascus pigment rubropunctatin, International Journal of Biological Macromolecules 2023, 242: 125058.

19. S Xiao, Z Lu, J Yang, X Shi, Y Zheng*, Phycocyanobilin from Arthrospira platensis: A potential photodynamic anticancer agent, Dyes and Pigments 2023, 219: 111516.

20. C He, B Yu, Y Lv, Y Huang, J Guo, L Li, M Chen, Y Zheng, M Liu, S Guo*, X Shi, J Yang*, Biomimetic Asymmetric Composite Dressing by Electrospinning with Aligned Nanofibrous and Micropatterned Structures for Severe Burn Wound Healing, ACS Applied Materials & Interfaces 2022, 14, 29, 32799-32812.

21. Z Zhang, J Guo, Y He, J Han, M Chen, Y Zheng, S Zhang, S Guo*, X Shi, J Yang^?, An injectable double network hydrogel with hemostasis and antibacterial activity for promoting multidrug-resistant bacteria infected wound healing, Biomaterials Science 2022, 10, 3268?3281.

22. G Wang*, Z Jiang, Q Xiao, C Jiang, X Shi*,Visible spectrophotometric assay for characterization of ω-transaminases, Analytical Biochemistry 2022, 658:114933

23. S Li, X Zhong, Y Xu, Y Zheng*, X Shi, F Li, S Guo, J Yang*, Smartphone-based reading system integrated with phycocyanin-enhanced latex nanospheres immunoassay for on-site determination of aflatoxin B1 in foodstuffs, Food Chemistry 2021, 360, 130019.

24. J Yang, Yufeng Huang, Jiajia Dai, Xianai Shi, Yunquan Zheng*, A sandwich structure composite wound dressing with firmly anchored silver nanoparticles for severe burn wound healing in a porcine model, Regenerative Biomaterials 2021, 8, rbab037.

25. Li F*, Wang L, Luo Y, Shi X*. Safety assessment of desaminotyrosine: Acute, subchronic oral toxicity, and its effects on intestinal microbiota in rats. Toxicology and Applied Pharmacology 2021, 417: 115464.

26. Y Yang, Q Liu, X Shi, Q Zheng, L Chen*, Y Sun*, Advances in plant-derived natural products for antitumor immunotherapy, Archives of Pharmacal Research 2021, 44, 987–1011.

27. L Li, X Zhong, Y Zheng*, S Guo, X Shi*, J Huang, Enhancement of biomass production and productivity of Arthrospira platensis GMPA7 using response surface monitoring methodology and turbidostatic cultivation strategy, Journal of Applied Phycology 2021, 33: 755-763.

28. X Feng, X Zhang, S Li, Y Zheng^?, X Shi, F Li, S Guo, J Yang^?, Preparation of aminated fish scale collagen and oxidized sodium alginate hybrid hydrogel for enhanced full-thickness wound healing, International Journal of Biological Macromolecules 2020, 164, 626–637.

29. Bangrui Yu, Chenhui He, Weibin Wang, Yafeng Ren, Jianmin Yang,* Shaobin Guo, Yunquan Zheng, and Xianai Shi*. Asymmetric Wettable Composite Wound Dressing Prepared by Electrospinning with Bioinspired Micropatterning Enhances Diabetic Wound Healing, ACS Applied Bio Materials 2020, 3, 5383?5394

30. Jimin Sun, Yafeng Ren, Weibin Wang, Huili Hao, Mingyu Tang, Zibo Zhang, Jianmin Yang*, Yunquan Zheng, and XianAi Shi*, Transglutaminase-catalyzed encapsulation of individual mammalian cells with biocompatible and cytoprotective gelatin nanoshells, ACS Biomaterials Science and Engineering 2020, 6, 2336?2345

31. Li F*, Li Y, Li Q, Shi X*. Eriobotrya japonica leaf triterpenoid acids ameliorate metabolic syndrome in C57BL/6J mice fed with high-fat diet. Biomedicine & Pharmacotherapy 2020, 132: 110866.

32. 楊建民, 郝慧麗, 王偉彬, 石賢愛*, 單哺乳動物細胞封裝技術(shù)研究進展, 中國科學: 生命科學2020, 50, 406?426. (綜述)

33. Lingling Wu, Hongming Ding, Xin Qu, Xianai Shi, Jianmin Yang, Mengjiao Huang, Jialu Zhang, Huimin Zhang, Jia Song, Lin Zhu, Yanling Song*, Yuqiang Ma*, and Chaoyong Yang*. Fluidic multivalent membrane   nanointerface enables synergetic enrichment of circulating tumor cells with   high efficiency and viability, Journal of the American Chemical Society 2020, 142, 4800?4806.

34. Zeng Wei, Xianai Shi^#, Rong Lian,Weibin Wang, Wenrong Hong and Shaobin Guo. Exclusive Production of Gentamicin C1a from Micromonospora purpurea by Metabolic Engineering, Antibiotics 2019, 8, 267-275; doi:10.3390 /antibiotics 8040267

35. Hu Shengxue, Cai Xianqun, Qu Xin, Yu Bangrui, Yan Chenyan, Yang Jianmin, Li Feng, Zheng Yunquan, Shi Xianai^*. Preparation of biocompatible wound dressings with long-term antimicrobial activity through covalent bonding of antibiotic agents to natural polymers, International Journal of Biological Macromolecules 2018:1879-0003

36. Xianqun Cai, Shengxue Hu, Bangrui Yu, Yilei Cai, Jianmin Yang, Feng Li, Yunquan Zheng, Xianai Shi^*. Transglutaminase-catalyzed preparation of crosslinked carboxymethyl chitosan/carboxymethyl cellulose/collagen composite membrane for postsurgical peritoneal adhesion prevention, Carbohydrate Polymers 2018, 20:201-210. https://doi.org/10.1016/j.carbpol.2018.08.065

37. Yunquan Zheng, Liangbin Li, Xianai Shi*, Zhijian Huang, Feng Li, Jianmin Yang and Yanghao Guo. Nonionic surfactants and their effects on asymmetric reduction of 2-octanone with Saccharomyces cerevisiae. AMB Express 2018, 8:111-117. https://doi.org/10.1186/s13568-018-0640-1

38. Feng Li, Qingxian Li, Xianai Shi*, Yanghao Guo. Maslinic acid inhibits impairment of endothelial functions induced by high glucose in HAEC cells through improving insulin signaling and oxidative stress. Biomedicine & Pharmacotherapy 2017, 95:904-913. doi: 10.1016/j.biopha.2017.09.001

39. 石賢愛^#，林海虹，王曉萍，方世銀. 醇脫氫酶同工酶基因表達與釀酒酵母催化2-辛酮不對稱還原的關(guān)系. 過程工程學報 2017, 17(4):827-833

40. 陳蔭楠，劉震，石賢愛*, 王祖鑫. 密碼子優(yōu)化提高多粘類芽孢桿菌β-葡萄糖苷酶異源表達量. 中國生物化學與分子生物學報 2017, 33(4):414-422

41. 李鋒，方世銀，石賢愛*. 有機介質(zhì)處理釀酒酵母對其催化不對稱還原反應性能的影響. 過程工程學報 2017, 17(6):1281-1286

42. 陳倩，陳蔭楠，陳東海，林海虹，石賢愛*. 基于單鏈抗體的呋喃唑酮 酶聯(lián)免疫檢測方法的建立. 食品科學 2017, 38(20):242-247

43. 陳蔭楠，陳華，石賢愛*，葉小軍，樊海平. 抗呋喃唑酮單克隆抗體的制備及其應用. 食品科學 2016, 3:157-163

44. 何麗妃，薛原楷，石賢愛*. 特殊反應體系中交聯(lián)β-葡萄糖苷酶聚集體催化合成紅景天苷. 過程工程學報 2015, 2:313-317

45. 劉震，陳倩，陳蔭楠，王祖鑫，朱秋享，石賢愛*. 枯草芽孢桿菌β-糖苷酶的克隆表達、體外定向進化及結(jié)構(gòu)模擬. 微生物學報 2015, 55(10):1273-1283

46. 石賢愛^#，裴世鋒，李向楠，朱秋享，葉小軍，樊海平. 基于不同半抗原的呋喃唑酮代謝物免疫檢測方法的建立與比較. 食品科學 2014, 35(8):36-42

47. 吳星濤，薛原楷，石賢愛*. 磁性交聯(lián) β-葡萄糖苷酶聚集體的制備及性質(zhì). 生物物理學報 2013, 29(10):769-778

48. Xian-Ai Shi^#, Hang Wang, Hao Wang, Zhiming Wang, and Chun Meng. Transferring chromosome DNA fragments from multiple donor cells into a host strain for yeast strain improvement, Canadian Journal of Microbiology 2012, 58: 760–766

49. 岳磊，林瓊妹，許格，林磊，石賢愛*. 含離子液體介質(zhì)中酶催化糖基化合成4-羥基苯乙基β-D-葡萄糖苷. 分子催化 2011, 25(3):269-275

50. 楊錦，方世銀，石賢愛*. 水相中釀酒酵母催化3-氯-1-苯丙酮的不對稱還原反應. 過程工程學報 2011, 11(2):324-328

51. 石賢愛^#，李聰穎，傅娟，孟春，郭養(yǎng)浩，婁文勇，吳虹，宗敏華. 表面活性劑對面包酵母細胞催化2－辛酮不對稱還原反應的影響. 過程工程學報2009, 10(2)339-343

52. Shi Xian-Ai^#, Zong, Min-Hua*, Lou Wen-Yong. Effect of ionic liquids on catalytic characteristics of horse liver alcohol dehydrogenase. Chinese Journal of Chemistry 2006, 24 (11): 1643-1647

53. 石賢愛^#，婁文勇，宗敏華，郭養(yǎng)浩，孟春. Candida rugosa脂肪酶催化(R,S)-2-辛醇酯交換反應的對映選擇性.華南理工大學學報(自然科學版) 2006, 34(12):30-34

54. 石賢愛^#，宗敏華，孟春，郭養(yǎng)浩. 含離子液體BMIm?Cl反應介質(zhì)中馬肝醇脫氫酶的催化特性, 催化學報 2005, 26(11):982-986

獲獎情況

獲5項福建省科學技術(shù)獎和beat365在線體育官網(wǎng)青年“五四”獎章。

其他

任beat365在線體育官網(wǎng)beat365在線體育官網(wǎng)副院長（分管科研和研究生培養(yǎng)）、科技部健康醫(yī)療器械國際科技合作基地副主任、福建省醫(yī)療器械和生物醫(yī)藥重點實驗室副主任、福建省海洋生物制品綠色制造工程研究中心副主任、福州市海洋生物制品行業(yè)創(chuàng)新中心主任、beat365在線體育官網(wǎng)藥物生物技術(shù)與工程研究所所長、福建省科技重大專項“海洋生物資源高值化利用技術(shù)研究”首席專家、福州市十四五生物醫(yī)藥戰(zhàn)略性新興產(chǎn)業(yè)集群建設方案撰寫組組長。

課題組網(wǎng)站（石賢愛教授課題組）：https://www.x-mol.com/groups/xianai_shi