職務(wù)：副研究員/碩士生導(dǎo)師

學(xué)歷：博士

電子郵件： zdluoman1987@163.com

主要研究方向：腫瘤新抗原/溶瘤免疫治療、放療與免疫治療、納米光學(xué)診療

教育工作經(jīng)歷：

1.2006/9–2010/7，吉林農(nóng)業(yè)大學(xué)，生物技術(shù)，學(xué)士

2.2010/9–2013/12，華南師范大學(xué)，生物物理學(xué)，碩士

3.2013/7–2016/9，福建醫(yī)科大學(xué)孟超肝膽醫(yī)院，研究員實(shí)習(xí)員

4.2016/9–2020/8，福建醫(yī)科大學(xué)孟超肝膽醫(yī)院，助理研究員員

5.2017/9–2020/12，beat365在線(xiàn)體育官網(wǎng)，分析化學(xué)，博士

6. 2021/1–至今，beat365在線(xiàn)體育官網(wǎng)孟超醫(yī)學(xué)與交叉科學(xué)中心，副研究員

7.2021/1–至今，福建醫(yī)科大學(xué)孟超肝膽醫(yī)院，副研究員

教學(xué)簡(jiǎn)介：

無(wú)

科研簡(jiǎn)介：主要從事光學(xué)診療納米制劑、放療增敏劑、超分子藥物配位自主組、納米疫苗及溶瘤病/NK等靶向遞送與免疫治療研究。已在Nano Letters, Angewandte Chemie, ACS Nano, Advanced Science, Small, iScience, Chemical Engineering Journal, Theranostics, Chemical Science, ACS applied materials & interfaces及科學(xué)通報(bào)等期刊發(fā)表SCI論文30篇，ESI高引論文3篇，公開(kāi)國(guó)家發(fā)明專(zhuān)利11項(xiàng)（授權(quán)6項(xiàng)，第一發(fā)明人4項(xiàng)），PCT專(zhuān)利1項(xiàng)； 2021年入選福建省高層次人才（C類(lèi)）；2022年獲福建省杰出青年項(xiàng)目資助；主持國(guó)自然基金青年項(xiàng)目1項(xiàng)，參與國(guó)家及重點(diǎn)項(xiàng)目等4項(xiàng)；主持福建省科技創(chuàng)新聯(lián)合資金及面上、杰青項(xiàng)目等4項(xiàng)；主持福建省中青年骨干項(xiàng)目1項(xiàng)；

社會(huì)兼職：中國(guó)抗癌協(xié)會(huì)抗癌藥物專(zhuān)業(yè)委員會(huì)青年委員（2020），《ACS Nano》、《Advanced Science》、《Small》、《Chemical Engineering Journal》、《ACS applied materials & interfaces》，《Biomaterials》、《Acta biaomaterials》等雜志審稿人。

科研項(xiàng)目：

1. 2019.01---2021.12，國(guó)家自然科學(xué)基金青年項(xiàng)目：智能核殼型金屬有機(jī)配位聚合物用于磁共振引導(dǎo)的腫瘤近紅外二區(qū)光熱協(xié)同治療(61805041)，25萬(wàn)元，主持，結(jié)題；

2. 2022.08.01---2025.08.01福建省自然科學(xué)基金杰青項(xiàng)目：新生抗原疫苗遞送載體設(shè)計(jì)及其應(yīng)用，2022J06034，30萬(wàn)，主持，在研；

3. 2022.10-2025.10，福建省科技創(chuàng)新聯(lián)合資金項(xiàng)目：新型放療增敏納米材料提高腫瘤放射治療效應(yīng)的研究（交叉學(xué)科項(xiàng)目）, 2021Y9216，200萬(wàn)，主持，在研；

4. 2022.08---2024.08福建省衛(wèi)健委中青年骨干項(xiàng)目：新生抗原疫苗胞質(zhì)遞送增強(qiáng)肝癌個(gè)性化免疫治療，2021GGB020，5萬(wàn)，主持，在研；

5. 2020.11---2023.11，福建省自然科學(xué)基金面上項(xiàng)目：基于光敏配位聚合物調(diào)控腫瘤微環(huán)境增強(qiáng)肝癌光化學(xué)-免疫治療研究(2020J011154)，7萬(wàn)元，主持，在研；

6. 2016/04-2019/04，福建省自然科學(xué)基金面上項(xiàng)目：還原性敏感光敏化DNA-AQ4N適配體用于靶向肝癌監(jiān)測(cè)及光動(dòng)力誘導(dǎo)乏氧性化療聯(lián)合治療(2016J01174)，4萬(wàn)元，主持，結(jié)題；

7.  2015/04-2018/03，福州市科技計(jì)劃項(xiàng)目：半導(dǎo)體聚合物納米膠束用于肝癌光聲-核磁共振成像及光學(xué)協(xié)同治療的研究(2015-S-143-11)，5萬(wàn)元，主持，結(jié)題；

8.  2014/07-2017/06，福州市衛(wèi)生系統(tǒng)科技計(jì)劃項(xiàng)目：Gd/Au雜化脂質(zhì)體作為肝癌靶向的CT/MRI雙模態(tài)影像及熱療探針的應(yīng)用研究(2014-S-w25)，4萬(wàn)元，主持，結(jié)題；

9.  2016/01-2019/12，國(guó)家自然科學(xué)基金面上項(xiàng)目： 腫瘤特異靶向的長(zhǎng)循環(huán)多功能納米膠束用于肝癌的光聲成像及光熱/光動(dòng)力協(xié)同治療研究(61575044)，60萬(wàn)元，參與，結(jié)題；

10.  2016/01-2019/12，國(guó)家自然科學(xué)基金“促進(jìn)海峽兩岸科技合作聯(lián)合基金”：光聲/MRI/CT多模態(tài)成像監(jiān)測(cè)原發(fā)性肝癌靶向微創(chuàng)治療(U1505221)，215萬(wàn)元，參與，結(jié)題；

11.  2018/01-2022/12，國(guó)家自然科學(xué)基金“國(guó)家重大科研儀器研制項(xiàng)目”：基于波前整形的高光譜成像引導(dǎo)的腫瘤光熱/光動(dòng)力雙模治療手術(shù)系統(tǒng)(61727823)，780萬(wàn)元，參與，在研；

12.  2020/01-2023/12, 國(guó)家自然科學(xué)基金重大研究計(jì)劃“基于核酸適體的膀胱癌相關(guān)標(biāo)志物發(fā)現(xiàn)和可視化分析(91959102)”80萬(wàn)，參與，在研；

已發(fā)表論文：（*為通訊作者）

(1) Da Zhang*#, Chenwei Jiang#, Xiaoyuan Zheng#, Zhiwen Lin#, Qiuyu Zhuang, Huanzhang Xie, Yuzhi Liang, Yu Xu, Linsheng Cui, Xiaolong Liu*, Yongyi Zeng*. Normalization of Tumor Vessels by Lenvatinib-Based Metallo-Nanodrugs Alleviates Hypoxia and Enhances Calreticulin-Mediated Immune Responses in Orthotopic HCC and Organoids. Small (2023): 2207786 (IF: 15.153, 一區(qū))

(2) Ming Wu#, Hao Li#, Cao Zhang, Yingchao Wang, Cuilin Zhang, Yuting Zhang, Aoxue Zhong, Da Zhang*, Xiaolong Liu*. Silk-Gel Powered Adenoviral Vector Enables Robust Genome Editing of PD-L1 to Augment Immunotherapy across Multiple Tumor Models. Advanced Science (2023): 2206399. (IF: 17.521, 一區(qū))

(3) Qingfu Zhao#, Yunhao Wang#, Binyu Zhao#, Hengkai Chen, Zhixiong Cai, Youshi Zheng, Yongyi Zeng, Da Zhang*, and Xiaolong Liu* Neoantigen Immunotherapeutic-Gel Combined with TIM-3 Blockade Effectively Restrains Orthotopic Hepatocellular Carcinoma Progression. Nano Lett. 2022. 9;22(5):2048-2058. (IF: 11.189, 一區(qū), TOP)

(4) [2] Yunhao Wang#, Qingfu Zhao#, Binyu Zhao, Youshi Zheng, Qiuyu Zhuang, Naishun Liao, Peiyuan Wang, Zhixiong Cai, Da Zhang*, Yongyi Zeng*, Xiaolong Liu*. Remodeling Tumor-Associated Neutrophils to Enhance Dendritic Cell-Based HCC Neoantigen Nano-Vaccine E?ciency. Advanced Science. 2022, 2105631. (IF: 17.521, 一區(qū))

(5) Zhijin Fan, Cheng Jiang, Yichao Wang, Kaiyuan Wang, Jade Marsh, Da Zhang*, Xin Chen*, Liming Nie* Engineered Extracellular Vesicles as Intelligent Nanosystem for Next-Generation of Nanomedicine, Nanoscale Horiz, 2022,7, 682-714. (IF: 11.684, 一區(qū))

(6) [Da Zhang#, Tianhong Teng#, Qingfu Zhao#, Zhiwen Lin, Junrong Zhang, Xiaolong Liu, and Yongyi Zeng* Nanoparticles for Near-Infrared Light-Driven Singlet Oxygen and CO Gas Cogeneration for Pancreatic Adenocarcinoma Therapy, ACS Appl. Nano Mater. 2022, 5, 11, 16741–16752 (IF: 6.1, 二區(qū))

(7) Da Zhang#, Youshi Zheng#, Ziguo Lin, Xiaolong Liu, Juan Li*, Huanghao Yang*, Weihong Tan. Equipping Natural Killer Cells with Specific Targeting and Checkpoint Blocking for Enhanced Adoptive Immunotherapy in Solid Tumors. Angew Chem Int Ed Engl.2020.59,12022-12028. (IF: 16.823, 一區(qū), TOP)

(8) Da Zhang#, Ziguo Lin#, Ming Wu#, Zhixiong Cai, Youshi Zheng, Lei He, Zhenli Li, Jie Zhou, Liqin Sun, Geng Chen, Yongyi Zeng, Juan Li, Jingfeng Liu*, Huanghao Yang*, Xiaolong Liu*.Cytosolic Delivery of Thiolated Neoantigen Nano-vaccine Combined with Immune Checkpoint Blockade to Boost Anti-cancer T Cell Immunity. Advanced Science. 2021. 8, 2003504. (IF: 17.521, 一區(qū))

(9) Da Zhang#, Ziguo Lin#, Youshi Zheng, Jibin Song, Juan Li, Yongyi Zeng,* and Xiaolong Liu*. Ultrasound-Driven Biomimetic Nanosystem Suppresses Tumor Growth and Metastasis through Sonodynamic Therapy, CO Therapy, and Indoleamine 2,3-Dioxygenase Inhibition. ACS Nano, 2020. 14, 8985-8999. (IF: 18.027, 一區(qū))

(10) Chengyun Chen, Yuhong Tong, Youshi Zheng, Yingjun Shi, Zhaowei Chen, Juan Li, Xiaolong Liu, Da Zhang*, Huanghao Yang*. Cytosolic Delivery of Thiolated Mn-cGAMP Nanovaccine to Enhance the Antitumor Immune Responses. Small. 2021.2006970. (IF: 15.153, 一區(qū))

(11) Xianglian Liao, Youshi Zheng, Ziguo Lin, Yi Shen, Huiyun Lin, Xiaolong Liu, Da Zhang*, Buhong Li*. Self-assembled metallo-supramolecular nanoflowers for NIR / acidic-triggered multidrug release, long-term tumor retention and NIR-II fluorescence imaging-guided photo-chemotherapy. Chemical Engineering Journal. 2020. 400, 125882. (IF: 16.8, 一區(qū))

(12) Da Zhang#, Youshi Zheng#, Ziguo Lin, Shanyou Lan, Xiaolong Zhang, Aixian Zheng, Juan Li, Gang Liu, Huanghao Yang, Xiaolong Liu*, Jingfeng Liu*. Artificial Engineered Natural Killer Cells Combined with Antiheat Endurance as Powerful Strategy for Enhancing Photothermal- Immunotherapy Efficiency of Solid Tumors. Small. 2019. 15, 1970228. (IF: 15.153, 一區(qū))

(13) Da Zhang# , Cuilin Zhang# , Shanyou Lan, Yanbing Huang, Jingfeng Liu, Juan Li*, Xiaolong Liu*, Huanghao Yang* Near-Infrared Light Activated Thermosensitive Ion Channel to Remotely Control Transgene System for Thrombolysis Therapy. Small. 2019. 15, 1901176. (IF: 15.153, 一區(qū))

(14) Da Zhang#, Ming. Wu, Zhixiong Cai, Naishun Liao, Kun Ke, Hongzhi Liu, Ming Li, Gang Liu, Huanghao Yang, Xiaolong Liu* , Jingfeng Liu*. Chemotherapeutic Drug Based Metal–Organic Particles for Microvesicle-Mediated Deep Penetration and Programmable pH/NIR/Hypoxia Activated Cancer Photochemotherapy. Advanced Science, 2018. 5, 1700648. (IF: 17.521, 一區(qū))

(15) Da Zhang, Aixian Zheng, Juan Li, Ming Wu, Zhixiong Cai, Lingjie Wu, Zuwu Wei, Huanghao Yang, Gang Liu, Xiaolong Liu* , Jingfeng Liu*. Tumor Microenvironment Activable Self-Assembled DNA Hybrids for pH and Redox Dual-Responsive Chemotherapy / PDT Treatment of Hepatocellular Carcinoma, Advanced Science, 2017. 4, 1600460. (IF: 17.521, 一區(qū))

(16) Da Zhang, Aixian Zheng, Juan Li, Ming Wu, Lingjie Wu, Zuwu Wei, Naishun Liao, Xiaolong Zhang, Zhixiong Cai, Huanghao Yang, Gang Liu, Xiaolong Liu* , Jingfeng Liu*.Smart Cu(II)-aptamer complexes based gold nanoplatform for tumor micro-environment triggered programmable intracellular prodrug release, photodynamic treatment and aggregation induced photothermal therapy of hepatocellular carcinoma. Theranostics, 2017, 7,164-179. (IF: 11.556, 一區(qū))

(17) Da Zhang, Zhixiong Cai, Naishun Liao, Shanyou Lan, Ming Wu, Haiyan Sun, Zuwu Wei,Juan Li*, Xiaolong Liu*.pH / hypoxia programmable triggered cancer photo-chemotherapy based on a semiconducting polymer dot hybridized mesoporous silica framework. Chemical science, 2018. 9, 7390-7399. (IF: 9.825, 一區(qū))

(18) [Ming Wu#, Dongye Zheng#, Da Zhang #, Peiwen Yu, Lianli Peng, Feng Chen, Ziguo Lin,Zhixiong Cai, Jiong Li, Zuwu Wei, Xinyi Lin, Jingfeng Liu*, Xiaolong Liu*. Converting Immune Cold into Hot by Biosynthetic Functional Vesicles to Boost Systematic Antitumor Immunity. iScience, 2020. 23, 101341. (IF: 6.4, 二區(qū))

(19) Da Zhang, Ming Wu., Yongyi Zeng, Lingjie Wu, Qingtang Wang, Xiao Han, Xiaolong Liu*, Jingfeng Liu*.Chlorin e6 conjugated poly (dopamine) nanospheres as PDT / PTT dual-modal therapeutic agents for enhanced cancer therapy, ACS applied materials & interfaces, 2015. 7, 8176- 8187. (IF: 10.383, 二區(qū))

(20) Da Zhang, Hao Xu, Xiaolong Zhang, Yubin Liu, Ming Wu, Juan Li, Huanghao Yang, Gang Liu, Xiaolong Liu*, Jingfeng Liu*, Zhen Yuan. Self-Quenched Metal-Organic Particles as Dual-Mode Therapeutic Agents for Photoacoustic Imaging-Guided Second Near-Infrared Window Photochemotherapy. ACS applied materials & interfaces, 2018. 10, 25203-25212. (IF: 10.383, 二區(qū))

(21) Shanyou Lan, Ziguo Lin, Da Zhang*, Yongyi Zeng*, Xiaolong Liu.  Photocatalysis Enhancement for Programmable Killing of Hepatocellular Carcinoma through Self-Compensation Mechanisms based on Black Phosphorus Quantum Dot hybridized Nanocatalysts, ACS applied materials & interfaces, 2019. 11, 9804-9813. (IF: 10.383, 二區(qū))

(22) Yanlin Du#, Da Zhang#, Yiru Wang, Ming Wu, Cuilin Zhang, Youshi Zheng, Aixian Zheng*, Xiaolong Liu*. A highly stable multifunctional aptamer for enhancing antitumor immunity against hepatocellular carcinoma by blocking dual immune checkpoints Biomaterials Science. 2021. 9, 4159-4168. (IF: 7.590, 二區(qū))

(23) Youshi. Zheng, Cuilin. Zhang, Zishen. Lai, Yongyi. Zeng, Juan. Li, Da. Zhang* and Xiaolong. Liu*, Redirecting natural killer cells to potentiate adoptive immunotherapy in solid tumors through stabilized Y-type bispecifific aptamer. Nanoscale, 2021.13,11279. (IF: 8.307, 二區(qū))

(24) Liao, Naishun#, Da Zhang#, Ming Wu, Huanghao Yang, Xiaolong Liu*, and Jibin Song*. Enhancing therapeutic effects and in vivo tracking of adipose tissue-derived mesenchymal stem cells for liver injury using bioorthogonal click chemistry. Nanoscale. 2021.13,1813-1822. (IF: 8.307, 二區(qū))

(25) Tianhong Teng#, Ronggui Lin#, Ziguo Lin, Kun Ke, Xianchao Lin, Maoen Pan, Da Zhang*, Heguang Huang*, Photothermal augment stromal disrupting effects for enhanced Abraxane synergy chemotherapy in pancreatic cancer PDX mode. Biomaterials Science. 2020. 21, 8: 3278-3285. (IF: 7.590, 二區(qū))

(26) Da Zhang#, Ziguo Lin#, Shanyou Lan, Haiyan Sun*, Yongyi Zeng* Xiaolong Liu*. The Design of Janus Black Phosphorus Quantum dots@Metal-Organic Nanoparticles for Simultaneously Enhancing Environmental Stability and Photodynamic therapy Efficiency, Mater. Chem. Front., 2019, 3, 656-663. (IF: 8.4, 二區(qū))

(27) Da Zhang # , Xiao Lin# , Shanyou Lan# , Haiyan Sun, Xuandong Wang, Xiaolong Liu, Yun Zhang, and Yongyi Zeng*.  Localized Surface Plasmon Resonance Enhanced Singlet Oxygen Generation and Light Absorption Based on Black Phosphorus@AuNPs Nanosheet for Tumor Photodynamic / Thermal Therapy. Particle&Particle Systems Characterization, 2018. 35, 1800010. (IF: 3.31, 三區(qū))

(28) Da Zhang, Ming Wu, Yongyi Zeng, Naishun Liao, Zhixiong Cai, Gang Liu, Xiaolong Liu*, Jingfeng Liu*.Lipid micelles packaged with semiconducting polymer dots as simultaneous MRI / photoacoustic imaging and photodynamic / photothermal dual-modal therapeutic agents for liver cancer. Journal of Materials Chemistry B, 2016. 4, 589-599. (IF: 6.331, 二區(qū))

(29) Zhixiong Cai#, Da Zhang#, Xinyi Lin, Yunzhu Chen, Ming Wu, Zuwu Wei, Zhenxi Zhang1, Xiaolong Liu5,2,3 and Cuiping Yao5,1 (2017). Glutathione responsive micelles incorporated with semiconducting polymer dots and doxorubicin for cancer photothermal-chemotherapy. Nanotechnology, 28(42), 425102.

(30) 張達(dá), 周非凡, 邢達(dá). 功能化氧化石墨烯的靶向腫瘤成像與光熱治療. 科學(xué)通報(bào), 2013; 7: 586-592.11

授權(quán)發(fā)明專(zhuān)利：

(1) 張達(dá);劉景豐;劉小龍;吳名,一種PEG修飾的二維納米片光熱轉(zhuǎn)換材料及其應(yīng)用.專(zhuān)利號(hào)ZL 201710655253.6；

(2) 張達(dá);劉小龍;吳名;劉景豐,腫瘤微酸性敏感的銅-藥物共配位自組裝納米粒及應(yīng)用.專(zhuān)利號(hào)ZL 201710102120.6；

(3) 張達(dá);劉景豐;劉小龍;曾永毅,一種光敏納米復(fù)合物及其制備方法和應(yīng)用.專(zhuān)利號(hào)ZL 201811343150.7；

(4) 張達(dá);曾永毅;劉景豐;劉小龍,黑磷量子點(diǎn)/鉑雜化介孔二氧化硅納米顆粒及制備方法和應(yīng)用.專(zhuān)利號(hào)ZL 201811343125.9；

(5) 劉景豐;劉小龍;黃愛(ài)民; 張達(dá), 用于肝癌多模態(tài)影像和光熱治療的多功能納米探針及應(yīng)用.專(zhuān)利號(hào)ZL 201310695697.4；

(6) 劉小龍;劉景豐; 張達(dá);曾永毅, 用于腫瘤早期診斷與光學(xué)治療的多功能納米膠束及其應(yīng)用. 專(zhuān)利號(hào)ZL 201510429203.7；（已轉(zhuǎn)化，金額120萬(wàn)元,見(jiàn)附件）；

(7) 劉小龍; 張達(dá);鄭友世;蔡志雄;蘇小平.一種人工改造自然殺傷性細(xì)胞及其制備與應(yīng)用.專(zhuān)利號(hào)201910324655.7；

(8) 楊黃浩;李娟; 張達(dá);劉小龍, 含有至少2個(gè)硫原子的雜環(huán)化合物在制備納米疫苗中的應(yīng)用及制得的納米疫苗.專(zhuān)利號(hào)202010330996.8；

(9) 鄭友世;劉小龍; 張達(dá);林自國(guó). 一種核酸適體功能化NK細(xì)胞及其制備與應(yīng)用.專(zhuān)利號(hào)202010530479.5；

(10) 劉景豐;劉小龍;鄭友世; 張達(dá);曾永毅.一種增強(qiáng)NK細(xì)胞對(duì)腫瘤細(xì)胞靶向殺傷力的培養(yǎng)方法.專(zhuān)利號(hào)202010353458.0；

(11) 吳名; 張達(dá);劉小龍;劉景豐;曾永毅.用于聲動(dòng)力/氣體協(xié)同抗腫瘤治療的仿生納米材料及其制備方法.專(zhuān)利號(hào)202010555452.1；

(12) 楊黃浩;李娟;張達(dá);劉小龍.APPLICATION OF HETEROCYCLIC COMPOUND CONTAINING AT LEAST TWO SULFUR ATOMS IN PREPARING NANO-VACCINE AND PREPARED NANO-VACCINE. PCT/CN2020 / 134162.

獲獎(jiǎng)情況

2022年福建自然科學(xué)優(yōu)秀學(xué)術(shù)論文一等獎(jiǎng);

2022年福州市自然科學(xué)優(yōu)秀學(xué)術(shù)論文一等獎(jiǎng);

2021年福建省科學(xué)技術(shù)進(jìn)步獎(jiǎng)一等獎(jiǎng)（4/10）;

2020年福建醫(yī)學(xué)科技獎(jiǎng)二等獎(jiǎng)（4/7）；

2020年醫(yī)學(xué)科技突出貢獻(xiàn)工作者；

2014年福州市十佳創(chuàng)新能手；