職稱：副研究員

學歷：博士

電話：0591-22866373

電子郵件： ypxie@fzu.edu.cn

研究方向：微藻生物技術、生物發酵與代謝調控、生物物質分離純化

教育工作經歷：

2019.09-至今：福州海洋研究院海洋生物制造技術研發中心，常務副主任

2017.12-至今：海洋生物高值高質化利用技術創新服務平臺，常務副主任

2017.03-至今：福建省海產品廢棄物綜合利用工程技術研究中心，常務副主任

2015.08-至今：福州市海產品高值化利用行業技術創新中心，常務副主任

2014.08-至今：beat365在線體育官網beat365在線體育官網，助理研究員、副研究員

2012.09-2013.02：臺灣成功大學張嘉修（Jo-Shu Chang）教授實驗室，訪學

2004.09-2014.07：廈門大學，化學化工學院，工學學士、工學碩士、工學博士

教學簡介：

主講本科生課程《生物分離工程》，碩士研究生課程《綠色生物制造》、《生物資源開發利用》。指導研究生多次獲得國家獎學金、福建省優秀學位論文、beat365在線體育官網優秀學位論文、beat365在線體育官網研究生高水平學術成果獎等。

科研簡介：

主要從事微藻生物技術、生物發酵與代謝調控、生物物質分離純化等領域的研究工作。已先后主持國家“十三五”海洋經濟創新發展示范項目子課題、國家自然科學基金項目、福建省自然科學基金項目、福州市市校（院所）科技合作項目和福州海洋研究院科技項目等10余項，并作為技術負責人參與福建省海洋高新產業發展專項、福建省科技廳高校產學合作重大項目、福州市省級海洋經濟發展補助資金項目等10余項。以第一作者/通訊作者身份在Bioresour. Technol., Chem. Eng. J., Biotechnol. Biof. Biop., Algal Res., Mar. Drugs, Biotechnol. J., Biochem. Eng. J.等期刊上發表學術論文30余篇（中科院JCR大類學科1區Top期刊11篇，2區期刊12篇），作為共同作者發表學術論文30余篇，論文總被引1300余次（WOS），H指數24（WOS）。申請發明專利22件，已授權發明專利10件。獲福建省科學技術進步獎三等獎1項。2021年入選福建省級高層次人才C類。

社會兼職：

民盟福建省生態環境委員會委員；民盟beat365在線體育官網委員會組織委員；福建省科技特派員；福州市科技特派員；擔任Bioresour. Technol., Chem. Eng. J., Env. Sci. Ecotechnol., J. Hazard. Mater., J. Clean. Prod., Biotechnol. Biofuels, Algal Res., J. Taiwan Inst. Chem. E., Front. Microbiol., Front. Bioeng. Biotech., Biochem. Eng. J., Process Biochem., Int. J. Hydrogen Energ.等多本SCI期刊審稿人。

主要科研項目：

（1）國家“十三五”海洋經濟創新發展示范項目，海洋生物高值高質化利用技術創新服務平臺，2016-2019，子平臺負責人。

（2）國家“十三五”海洋經濟創新發展示范項目，海洋微藻高值化產品開發及產業鏈建設，2017-2019，子課題負責人。

（3）國家“十三五”海洋經濟創新發展示范項目，魷魚內臟高值化產品開發及年產350噸海洋農用制品生產線建設，2017-2019，子課題負責人。

（4）國家自然科學基金應急管理項目，海洋衣藻自養積累葉黃素的調控機制研究， 2017-2017，主持。

（5）福建省海洋高新產業發展專項項目，海洋微藻開發利用與水產養殖廢水凈化的耦合處理關鍵技術研發，2016-2018，技術負責人。

（6）2019年福州市省級海洋經濟發展補助資金項目，低值海魚綜合利用關鍵技術研發及產業化，2019-2020，技術負責人。

（7）2022年度福州海洋研究院科技項目，海洋小球藻高密度異養聯產蛋白質和葉黃素的關鍵技術開發及中試熟化，2022-2024，主持。

代表性論文：（*為通訊作者）

(1) Ruijuan Ma#, Zhen Zhang#, Hong Fang, Xinyu Liu, Shih-Hsin Ho, Youping Xie*, Jianfeng Chen*. Unveiling the underlying molecular mechanisms of high lutein production efficiency in Chlorella sorokiniana FZU60 under a mixotrophy/photoautotrophy two-stage strategy by transcriptomic, physiological, and biochemical analyses. Biotechnology for Biofuels and Bioproducts, 2023, 16: 47.

(2) Hong Fang, Junjie Liu, Ruijuan Ma*, Yiping Zou, Shih-Hsin Ho, Jianfeng Chen, Youping Xie*. Functional characterization of lycopene b- and e-cyclases from a lutein-enriched green microalga Chlorella sorokiniana FZU60. Marine Drugs, 2023, 21: 418.

(3) Ruijuan Ma#, Yuanwei You#, Xinyu Liu, Shih-Hsin Ho, Youping Xie*, Jianfeng Chen*. Highly efficient co-production of fucoxanthin and eicosapentaenoic acid by heterotrophic cultivation of a newly isolated microalga Nitzschia sp. FZU62. Algal Research, 2023, 71: 103046.

(4) Youping Xie^#, Zhen Zhang^#, Ruijuan Ma^#, Xinyu Liu, Miao Miao, Shih-Hsin Ho, Jianfeng Chen, Yoong Kit Leonge, Jo-Shu Chang*. High-cell-density heterotrophic cultivation of microalga Chlorella sorokiniana FZU60 for achieving ultra-high lutein production efficiency. Bioresource Technology, 2022, 365: 128130.

(5) Hongling Ke^#, Ruijuan Ma^#, Xinyu Liu, Youping Xie*, Jianfeng Chen*. Highly effective peptide-calcium chelate prepared from aquatic products processing wastes: stickwater and oyster shells. LWT-Food Science and Technology, 2022, 168: 113947.

(6) Youping Xie, Kuan Shiong Khoo, Kit Wayne Chew, Vishno Vardhan Devadas, Sue Jiun Phang, Hooi Ren Lim, Saravanan Rajendran, Pau Loke Show*. Advancement of renewable energy technologies via artificial and microalgae photosynthesis. Bioresource Technology, 2022, 363: 127830.

(7) Ruijuan Ma^#, Xinyi Tao^#, Elvis T. Chua^#, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Jianfeng Chen. Enhancing astaxanthin production in Haematococcus pluvialis QLD by a pH steady NaHCO₃-CO₂-C/NH₄Cl-N culture system. Algal Research, 2022, 64: 102697.

(8) Ruijuan Ma^#, Zhen Zhang^#, Zhuzhen Tang, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Jianfeng Chen. Enhancement of co-production of lutein and protein in Chlorella sorokiniana FZU60 using different bioprocess operation strategies. Bioresources and Bioprocessing, 2021, 8: 82.

(9) Ruijuan Ma, Zhen Zhang, Shih-Hsin Ho, Chengxu Ruan, Jun Li, Youping Xie*, Xinguo Shi, Lemian Liu, Jianfeng Chen*. Two-stage bioprocess for hyper-production of lutein from microalga Chlorella sorokiniana FZU60: Effects of temperature, light intensity, and operation strategies. Algal Research, 2020, 52: 102119.

(10) Ruijuan Ma^#, Baobei Wang^#, Elvis T. Chua^#, Xurui Zhao, Kongyong Lu, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Yinghua Lu, Jianfeng Chen*. Comprehensive utilization of marine microalgae for enhanced co-production of multiple compounds. Marine Drugs, 2020, 18: 467.

(11) Youping Xie, Jun Li, Shih-Hsin Ho, Ruijuan Ma*, Xinguo Shi, Lemian Liu, Jianfeng Chen. Pilot-scale cultivation of Chlorella sorokiniana FZU60 with a mixotrophy/photoautotrophy two-stage strategy for efficient lutein production. Bioresource Technology, 2020, 314: 123767.

(12) Ruijuan Ma, Xurui Zhao, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Youping Xie*, Jianfeng Chen*, Yinghua Lu. Co-production of lutein and fatty acid in microalga Chlamydomonas sp. JSC4 in response to different temperatures with gene expression profiles. Algal Research, 2020, 47: 101821.

(13) Youping Xie, Jun Li, Ruijuan Ma, Shih-Hsin Ho, Xinguo Shi, Lemian Liu, Jianfeng Chen*. Bioprocess operation strategies with mixotrophy/photoinduction to enhance lutein production of microalga Chlorella sorokiniana FZU60. Bioresource Technology, 2019, 290: 121798.

(14) Ruijuan Ma, Xurui Zhao, Youping Xie*, Shih-Hsin Ho, Jianfeng Chen*. Enhancing lutein productivity of Chlamydomonas sp. via high-intensity light exposure with corresponding carotenogenic genes expression profiles. Bioresource Technology, 2019, 275: 416-420.

(15) Kongyong Lu^#, Xurui Zhao^#, Shih-Hsin Ho, Ruijuan Ma*, Youping Xie*, Jianfeng Chen. Biorefining and the functional properties of proteins from lipid and pigment extract residue of Chlorella pyrenoidosa. Marine Drugs, 2019, 17(8): 454.

(16) Youping Xie, Kongyong Lu, Xurui Zhao, Ruijuan Ma, Jianfeng Chen*, Shih-Hsin Ho*. Manipulating nutritional conditions and salinity-gradient stress for enhanced lutein production in marine microalga Chlamydomonas sp. Biotechnology Journal, 2019, 14: 1800380.

(17) Xurui Zhao, Ruijuan Ma, Xiaoting Liu, Shih-Hsin Ho, Youping Xie*, Jianfeng Chen*. Strategies related to light quality and temperature to improve lutein production of marine microalga Chlamydomonas sp. Bioprocess and Biosystems Engineering, 2019, 42: 435-443.

(18) Ying Shen, Sha Wang, Shih-Hsin Ho, Youping Xie*, Jianfeng Chen*. Enhancing lipid production in attached culture of a thermotolerant microalga Desmodesmus sp. F51 using light-related strategies. Biochemical Engineering Journal, 2018, 129: 119-128.

(19) Ying Shen, Huan Li, Wenzhe Zhu, Shih-Hsin Ho, Wenqiao Yuan, Jianfeng Chen, Youping Xie*. Microalgal-biochar immobilized complex: A novel efficient biosorbent for cadmium removal from aqueous solution. Bioresource Technology, 2017, 244: 1031-1038.

(20) Youping Xie, Xurui Zhao, Jianfeng Chen, Xuqiu Yang, Shih-Hsin Ho, Baobei Wang, Jo-Shu Chang, Ying Shen*. Enhancing cell growth and lutein productivity of Desmodesmus sp. F51 by optimal utilization of inorganic carbon sources and ammonium salt. Bioresource Technology, 2017, 244: 664-671.

(21) Youping Xie, Shih-Hsin Ho, Ching-Nen Nathan Chen, Chun-Yen Chen, Keju Jing, I-Son Ng, Jianfeng Chen, Jo-Shu Chang*, Yinghua Lu*. Disruption of thermo-tolerant Desmodesmus sp. F51 in high pressure homogenization as a prelude to carotenoids extraction. Biochemical Engineering Journal, 2016, 109: 243-251.

(22) Youping Xie, Yiwen Jin, Xianhai Zeng, Jianfeng Chen, Yinghua Lu, Keju Jing*. Fed-batch strategy for enhancing cell growth and C-phycocyanin production of Arthrospira (Spirulina) platensis under phototrophic cultivation. Bioresource Technology, 2015, 180: 281-287.

獲獎情況：

2022年，beat365在線體育官網優秀碩士學位論文指導教師

2021年，福建省級高層次人才C類

2020年，福建省優秀碩士學位論文指導教師

2020年，beat365在線體育官網優秀碩士學位論文指導教師

2019年，福建省優秀碩士學位論文指導教師

2019年，beat365在線體育官網優秀碩士學位論文指導教師

2018年，2017年度福建省科技進步獎三等獎，福建省人民政府

2017年，Bioresource Technology期刊杰出審稿人，Elsevier

2017年，Algal Research期刊杰出審稿人，Elsevier

2016年，Biochemical Engineering Journal期刊杰出審稿人，Elsevier

個人網頁：https://www.researchgate.net/profile/Youping_Xie

https://webofscience.clarivate.cn/wos/author/record/AAD-3105-2020