職務(wù)：研究員/碩士生導(dǎo)師

學(xué)歷：博士

電子郵件：

wmmj0419@163.com

W1833@fzu.edu.cn

主要研究方向：腫瘤分子影像、抗腫瘤納米藥物、腫瘤免疫治療

教育工作經(jīng)歷：

1.2003/9–2007/6，武漢工程大學(xué)，應(yīng)用化學(xué)，學(xué)士

2.2007/9–2013/6，武漢大學(xué)，高分子化學(xué)與物理，博士（碩博連讀）

3.2013/10-2017/1，福建醫(yī)科大學(xué)孟超肝膽醫(yī)院，助理研究員

4.2017/2–2020/6，福建醫(yī)科大學(xué)孟超肝膽醫(yī)院，副研究員

5.2020/7至今，福建醫(yī)科大學(xué)孟超肝膽醫(yī)院，研究員

6.2018/2至今，beat365在線體育官網(wǎng)孟超醫(yī)學(xué)與交叉科學(xué)中心，碩士生導(dǎo)師

科研簡介：針對(duì)肝癌早期診斷困難、治療手段匱乏、療效不佳等瓶頸問題，開發(fā)基于功能生物材料的載體系統(tǒng)，實(shí)現(xiàn)小分子化療藥物、siRNA/CRISPR-Cas9/核酸疫苗等靶向遞送，用于肝癌的低毒、高效治療。已在Advanced Science, Molecular Therapy, iScience, Nano-Micro Letters, Theranostics, Advanced Healthcare Materials等國際刊物發(fā)表SCI論文30余篇。主持國家自然科學(xué)基金青年基金、中國博士后面上資助、福建省衛(wèi)生教育聯(lián)合攻關(guān)項(xiàng)目、福建省自然科學(xué)基金、福建省科技創(chuàng)新聯(lián)合資金項(xiàng)目、福建省衛(wèi)計(jì)委中青年骨干人才培養(yǎng)項(xiàng)目、福建省衛(wèi)計(jì)委青年科研課題、福州市科技計(jì)劃項(xiàng)目等多個(gè)項(xiàng)目。入選“福建省高層次人才”，“福建省青年拔尖人才”，“福州市高層次引進(jìn)人才”，“福州市閩都英才”等計(jì)劃。

社會(huì)兼職：beat365在線體育官網(wǎng)碩士生導(dǎo)師、武漢工程大學(xué)碩士生導(dǎo)師、中國抗癌協(xié)會(huì)抗癌藥物專業(yè)委員會(huì)青年委員、福建省醫(yī)學(xué)會(huì)外科學(xué)分會(huì)實(shí)驗(yàn)外科與轉(zhuǎn)化醫(yī)學(xué)學(xué)組委員。

科研項(xiàng)目：

1. 福州市對(duì)外科技合作項(xiàng)目，2022-Y-007，靶向PD-L1的CRISPR/Cas9腺病毒系統(tǒng)在腫瘤免疫治療中的應(yīng)用，2022.6-2024.6，30萬元。

2. 福建省自然科學(xué)基金，2022J011282，拮抗VEGF和PD-L1的仿生納米囊泡用于肝癌免疫治療的研究，2022.8-2025.8，7萬元。

3. 福州市科技創(chuàng)新創(chuàng)業(yè)人才培育計(jì)劃項(xiàng)目，2021-R-105，基于細(xì)胞膜囊泡的肝癌免疫治療新策略研究，2021.6-2023.5，30萬元。

4. 福州市衛(wèi)健委創(chuàng)新團(tuán)隊(duì)項(xiàng)目，2020-S-wt7，細(xì)胞膜材料在腫瘤免疫抑制性微環(huán)境調(diào)控中的研究，2020.10-2023.10，8萬元。

5. 福建省科技創(chuàng)新聯(lián)合資金項(xiàng)目，2019Y9046，細(xì)胞源性微囊泡協(xié)同增強(qiáng)抗腫瘤免疫效應(yīng)，2020.9-2023.8，30萬元。

6. 福建省衛(wèi)生教育聯(lián)合攻關(guān)計(jì)劃項(xiàng)目，2019-WJ-20，生物來源納米囊泡在腫瘤免疫治療中的研究，2019/12-2022/12，20萬元。

7. 國家自然科學(xué)基金青年基金，81601538，腫瘤信號(hào)分子觸發(fā)化學(xué)發(fā)光/超聲雙模成像和光動(dòng)力治療的新型納米探針研究，2017/01-2019/12，17萬元。

8. 中國博士后面上二等資助，2015M571959，雙重響應(yīng)性納米藥物載體用于靶向治療肝癌的研究，2015/06-2016/12，5萬元。

9. 福建省自然科學(xué)基金青年創(chuàng)新項(xiàng)目，2015J05175，腫瘤微環(huán)境觸發(fā)靶向定位的磁共振影像納米探針的研究，2015/04-2018/04，3萬元。

10. 福建省科技創(chuàng)新聯(lián)合資金項(xiàng)目，2016Y9061，腫瘤信號(hào)分子觸發(fā)“診療一體化”納米探針的研究，2016/09-2019/09，10萬元。

11. 福建省衛(wèi)計(jì)委青年科研課題，2014-1-75，基于智能電荷翻轉(zhuǎn)和還原響應(yīng)性雙功能聚合物納米粒輸送化療藥物的研究，2015/01-2017/01，3萬元。

12. 福建省衛(wèi)計(jì)委中青年骨干人才培養(yǎng)項(xiàng)目，2017-ZQN-75，化學(xué)發(fā)光用于腫瘤光動(dòng)力治療的研究，2017/09-2020/08，10萬元。

13. 福州市科技計(jì)劃項(xiàng)目，2014-S-139-6，新型聚乙二醇衍生物用于化療藥物的肝癌靶向可控輸送研究，2014/07-2017/07，5萬元。

已發(fā)表論文：（^#為第一作者，*為通訊作者）

(1) Lei Ding^#, Xiaolong Zhang^#, Peiwen Yu, Fang Peng, Yupeng Sun, Yanni Wu, Zijin Luo, Hongsheng Li, Yongyi Zeng, Ming Wu*, Xiaolong Liu*, Genetically Engineered Nanovesicles Mobilize Synergistic Antitumor Immunity by ADAR1 Silence and PDL1 Blockade, Molecular Therapy, 2023, DOI:10.1016/j.ymthe.2023.04.011.

(2) Ming Wu^#, Hao Li^#, Cao Zhang^#, Yingchao Wang^#, Cuilin Zhang, Yuting Zhang, Aoxue Zhong, Da Zhang*, Xiaolong Liu*, Silk-gel powered adenoviral vector enables robust genome editing of PD-L1 to augment immunotherapy across multiple tumor models, Advanced Science, 2023, 10, 2206399.

(3) Yiru Wang^#, Ming Wu^#, Xiaorong Wang^#, Peiyuan Wang, Zhaoyu Ning, Yongyi Zeng, Xiaolong Liu, Haiyan Sun*, Aixian Zheng*, Biodegradable MnO₂-based gene-engineered nanocomposites for chemodynamic therapy and enhanced antitumor immunity, Materials Today Bio, 2023, 18, 100531.

(4) Qianqian Mao^#, Juan Min^#, Rui Zeng^#, Haiqin Liu, Hao Li, Cao Zhang, Aixian Zheng, Jiumao Lin*, Xiaolong Liu*, Ming Wu*, Self-assembled traditional Chinese nanomedicine modulating tumor immunosuppressive microenvironment for colorectal cancer immunotherapy, Theranostics, 2022, 12, 6088-6105. *

(5) Mingbin Huang^#, Chao Xu^#, Sen Yang, Ziqian Zhang, Zuwu Wei*, Ming Wu*, Fangqin Xue*, Vehicle-Free Nanotheranostic Self-Assembled from Clinically Approved Dyes for Cancer Fluorescence Imaging and Photothermal/Photodynamic Combinational Therapy, Pharmaceutics, 2022, 14, 1074.

(6) Yanbing Cao^#, De Wei^#, Lixia Yang^#, Zijin Luo, Peiwen Yu, Hao Li, Cao Zhang, Xiaolong Liu, Fengshou Wu*, Ming Wu*, Yongyi Zeng*, Nanoplatform Self-Assembly from Small Molecules of Porphyrin Derivatives for NIR-II Fluorescence Imaging Guided Photothermal-Immunotherapy, Advanced Healthcare Materials, 2022, 11, 2102526.

(7) Jiong Li^#, Sijia Wang^#, Xinyi Lin, Yanbing Cao, Zhixiong Cai, Jing Wang, Zhenxi Zhang, Xiaolong Liu, Ming Wu*, Cuiping Yao*, Red blood cell?mimic nanocatalyst triggering radical storm to augment cancer immunotherapy, Nano-Micro Letters, 2022, 14, 57.

(8) Da Zhang^#, Ziguo Lin^#, Ming Wu^#, Zhixiong Cai, Youshi Zheng, Lei He, Zhenli Li, Jie Zhou, Liqin Sun, Geng Chen, Yongyi Zeng, Juan Li, Jingfeng Liu*, Huanghao Yang*, Xiaolong Liu*, Cytosolic Delivery of Thiolated Neoantigen Nano-Vaccine Combined with Immune Checkpoint Blockade to Boost Anti-Cancer T Cell Immunity, Advanced Science, 2021, 8, 2003504.

(9) Peiwen Yu^#, Dongye Zheng^#, Cuilin Zhang, Ming Wu*, Xiaolong Liu*, Protocol to prepare functional cellular nanovesicles with PD1 and TRAIL to boost antitumor response, Star Protocols, 2021, 2, 100324.

(10) Fangqin Xue, XiaoLin, Zhixiong Cai, Xiaolong Liu, Yuan Ma*, MingWu*, Doxifluridine-based pharmacosomes delivering miR-122 as tumor microenvironments-activated nanoplatforms for synergistic treatment of hepatocellular carcinoma, Colloids and Surfaces B: Biointerfaces, 2021, 197, 111367.

(11) Haolan Li, Liangliang Yue, Ming Wu*, Fengshou Wu*, Self-assembly of methylene violet-conjugated perylene diimide with photodynamic/photothermal properties for DNA photocleavage and cancer treatment, Colloids and Surfaces B: Biointerfaces, 2020, 196, 111351.

(12) Ming Wu^#, Dongye Zheng^#, Da Zhang^#, Peiwen Yu, Lianli Peng, Feng Chen, Ziguo Lin, Zhixiong Cai, Jiong Li, Zuwu Wei, Xinyi Lin, Jingfeng Liu*, Xiaolong Liu*, Converting immune cold into hot by biosynthetic functional vesicles to boost systematic antitumor immunity, iScience, 2020, 23, 101341.

(13) Dongye Zheng^#, Peiwen Yu^#, Zuwu Wei, Cheng Zhong, Ming Wu*, Xiaolong Liu*, RBC membrane camoufaged semiconducting polymer nanoparticles for near?infrared photoacoustic imaging and photothermal therapy, Nano-Micro Letters, 2020, 12, 94.

(14) Kecan Lin^#, Yanbing Cao^#, Dongye Zheng, Qin Li, Hui Liu, Peiwen Yu, Jiong Li, Yanan Xue，Ming Wu*, Facile phase transfer of hydrophobic Fe₃O₄@Cu_2-xS nanoparticles by red blood cell membrane for MRI and phototherapy in the second near-infrared window, Journal of Materials Chemistry B, 2020, 8, 1202-1211.

(15) Xiao Lin, Xiaofang Song, Yiwei Zhang, Yanbing Cao, Yanan Xue, Fengshou Wu, Faquan Yu*, Ming Wu*, Xunjin Zhu*, Multifunctional theranostic nanosystems enabling photothermal-chemo combination therapy of triple-stimuli-responsive drug release with magnetic resonance imaging, Biomaterials Science, 2020, 8,1875-1884.

(16) Xiao Lin, Yanbing Cao, Yanan Xue, Fengshou Wu, Faquan Yu*, Ming Wu*, Xunjin Zhu*, Multifunctional theranostic agents based on prussian blue nanoparticles for tumor targeted and MRI-guided photodynamic/photothermal combined treatment, Nanotechnology, 2020, 31, 135101.

(17) Yanbing Cao^#, Juan Min^#, Dongye Zheng, Jiong Li, Yanan Xue*, Faquan Yu*, Ming Wu*, Vehicle-saving theranostic probes based on hydrophobic iron oxide nanoclusters using doxorubicin as a phase transfer agent for MRI and chemotherapy, Chemical Communications, 2019, 55, 9015-9018.

(18) Xiao Lin, Yanbin Cao, Jiong Li, Dongye Zheng, Shanyou Lan, Yanan Xue, Faquan Yu*, Ming Wu*, Xunjin Zhu*, Folic acid-modified Prussian blue/polydopamine nanoparticles as an MRI agent for use in targeted chemo/photothermal therapy, Biomaterials Science, 2019, 7, 2996-3006.

(19) Jiong Li^#, Zuwu Wei^#, Xinyi Lin, Dongye Zheng, Ming Wu*, Xiaolong Liu*, Jingfeng Liu*, Programmable therapeutic nanodevices with circular amplification of H₂O₂ in the tumor microenvironment for synergistic cancer therapy, Advanced Healthcare Materials, 2019, 8, 1801627.

(20) Ming Wu, Lingjie Wu, Jiong Li, Da Zhang, Shanyou Lan, Xiaolong Zhang, Xinyi Lin, Gang Liu, Xiaolong Liu*, Jingfeng Liu*, Self-luminescing theranostic nanoreactors with intraparticle relayed energy transfer for tumor microenvironment activated imaging and photodynamic therapy, Theranostics, 2019, 9, 20-33.

(21) Xinyi Lin^#, Ming Wu^#, Ming Li, Zhixiong Cai, Haiyan Sun, Xionghong Tan,  Jiong Li, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, Photo-responsive hollow silica nanoparticles for light-triggered genetic and photodynamic synergistic therapy, Acta Biomaterialia, 2018, 76, 178-192.

(22) Ming Wu^#, Xinyi Lin^#, Da Zhang, Youshi Zheng, Ai-Xian Zheng, Bixing Zhao, Yongyi Zeng, Xiaolong Liu*, Jingfeng Liu*, Photoresponsive nanovehicle for two independent wavelength light-triggered sequential release of P-gp shRNA and doxorubicin to optimize and enhance synergistic therapy of multidrug-resistant cancer, ACS Applied Materials & Interfaces, 2018, 10, 19416-19427.

(23) Jiong Li, Xuandong Wang, Dongye Zheng, Xinyi Lin, Zuwu Wei, Da Zhang, Zhuanfang Li, Yun Zhang, Ming Wu*, Xiaolong Liu*, Cancer cell membrane-coated magnetic nanoparticles for MR/NIR ?uorescence dual-modal imaging and photodynamic therapy, Biomaterials Science, 2018, 6, 1834-1845.

(24) Ming Wu^#, Jiong Li^#, Xinyi Lin, Zuwu Wei, Da Zhang, Bixing Zhao, Xiaolong Liu*, Jingfeng Liu*, Reduction/photo dual-responsive polymeric prodrug nanoparticles for programmed siRNA and doxorubicin delivery, Biomaterials Science, 2018, 6, 1457-1468.

(25) Cuiping Yao^#, Ming Wu^#*, Cecheng Zhang, Xinyi Lin, Zuwu Wei, Youshi Zheng, Da Zhang, Zhenxi Zhang*, Xiaolong Liu*, Photoresponsive lipid-polymer hybrid nanoparticles for controlled doxorubicin release, Nanotechnology, 2017, 28, 255101.

(26) Lingjie Wu^#, Ming Wu^#, Xinyi Lin, Xiaolong Zhang, Xiaolong Liu*, Jingfeng Liu*, Magnetite nanocluster and paclitaxel loaded charge-switchable nanohybrids for MR Imaging and chemotherapy, Journal of Materials Chemistry B, 2017, 5: 849-857.

(27) Ming Wu, Qingtang Wang, Da Zhang, Naishun Liao, Lingjie Wu, Aimin Huang, Xiaolong Liu*, Magnetite nanocluster@poly(dopamine)-PEG@indocyanine green  nanobead with magnetic field-targeting enhanced MR imaging and photothermal therapy in vivo, Colloids and Surfaces B: Biointerfaces, 2016, 141, 467-475.

(28) Ming Wu, Da Zhang, Yongyi Zeng, Lingjie Wu, Xiaolong Liu*, Jingfeng Liu*, Nanocluster of superparamagnetic iron oxide nanoparticles coated with poly (dopamine) for magnetic field-targeting, highly sensitive MRI and photothermal cancer therapy, Nanotechnology, 2015, 26: 115102.（2015年度熱點(diǎn)論文）

(29) Ming Wu^#, Qingtang Wang^#, Xiaolong Liu*, Jingfeng Liu*, Highly efficient loading of doxorubicin in Prussian Blue nanocages for combined photothermal/chemotherapy against hepatocellular carcinoma, RSC Advances, 2015, 5, 30970-30980.

(30) Lingjie Wu^#, Ming Wu^#, Yongyi Zeng, Da Zhang, Aixian Zheng, Xiaolong Liu*, Jingfeng Liu*, Multifunctional PEG modified DOX loaded mesoporous silica nanoparticle@CuS nanohybrids as photo-thermal agent and thermal-triggered drug release vehicle for hepatocellular carcinoma treatment, Nanotechnology, 2015, 26, 025102.

授權(quán)發(fā)明專利：

(1) 發(fā)明人：吳名; 張達(dá); 劉小龍; 劉景豐; 曾永毅; 用于聲動(dòng)力/氣體協(xié)同抗腫瘤治療的仿生納米材料及其制備. 授權(quán)號(hào)：ZL202010555452.1

(2) 發(fā)明人：吳名; 劉景豐; 劉小龍; 曾永毅; 一種具有光響應(yīng)降解的瘤可寧前體化合物及其制備與應(yīng)用.授權(quán)號(hào)：ZL201710608245.6

獲獎(jiǎng)情況

福建省科技進(jìn)步一等獎(jiǎng)（7/10）. 2022

福建省自然科學(xué)優(yōu)秀學(xué)術(shù)論文三等獎(jiǎng)（1/2）. 2022

福建省醫(yī)學(xué)科技二等獎(jiǎng)（3/7）. 2020

福建省自然科學(xué)優(yōu)秀學(xué)術(shù)論文二等獎(jiǎng)（1/1）. 2018

英國物理學(xué)會(huì)“China Top Cited Author Award”（1/2）. 2018